E9PS95 · E9PS95_HUMAN
- ProteinMitochondrial glutamate carrier 1
- GeneSLC25A22
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids196 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Mitochondrial glutamate/H+ symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton. Plays a role in the control of glucose-stimulated insulin secretion.
Catalytic activity
- L-glutamate(in) + H+(in) = L-glutamate(out) + H+(out)L-glutamate (in)CHEBI:29985
+ H+ (in)CHEBI:15378= L-glutamate (out)CHEBI:29985+ H+ (out)CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMitochondrial glutamate carrier 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE9PS95
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-29 | Helical | ||||
Sequence: LINGGIAGLIGVTCVFPI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 6-93 | Solcar | ||||
Sequence: ISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGAAVNLTLVTPEKAIKLAANDFFRHQLSKD | ||||||
Repeat | 97-196 | Solcar | ||||
Sequence: LTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPF |
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length196
- Mass (Da)20,846
- Last updated2011-04-05 v1
- ChecksumAE77565A1EC40566
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9H936 | GHC1_HUMAN | SLC25A22 | 323 | ||
K4DIA2 | K4DIA2_HUMAN | SLC25A22 | 114 | ||
K4DIA8 | K4DIA8_HUMAN | SLC25A22 | 190 | ||
K4DIB0 | K4DIB0_HUMAN | SLC25A22 | 103 | ||
K4DIB3 | K4DIB3_HUMAN | SLC25A22 | 161 | ||
K4DIB4 | K4DIB4_HUMAN | SLC25A22 | 65 | ||
K4DIB6 | K4DIB6_HUMAN | SLC25A22 | 156 | ||
K4DIB8 | K4DIB8_HUMAN | SLC25A22 | 177 | ||
A0A0D9SEI9 | A0A0D9SEI9_HUMAN | SLC25A22 | 197 | ||
A0A0D9SG84 | A0A0D9SG84_HUMAN | SLC25A22 | 117 | ||
A0A0D9SFA8 | A0A0D9SFA8_HUMAN | SLC25A22 | 97 | ||
A0A0D9SFE1 | A0A0D9SFE1_HUMAN | SLC25A22 | 247 | ||
E9PQ36 | E9PQ36_HUMAN | SLC25A22 | 134 | ||
A0A0A6YYN8 | A0A0A6YYN8_HUMAN | SLC25A22 | 78 | ||
E9PJH7 | E9PJH7_HUMAN | SLC25A22 | 313 | ||
E9PJY0 | E9PJY0_HUMAN | SLC25A22 | 72 | ||
E9PI74 | E9PI74_HUMAN | SLC25A22 | 127 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 196 | |||||
Sequence: F |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP006621 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |