E9PS18 · E9PS18_HUMAN

  • Protein
    Delta(14)-sterol reductase TM7SF2
  • Gene
    TM7SF2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase TM7SF2
  • EC number
  • Short names
    Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Sterol C14-reductase
    • Transmembrane 7 superfamily member 2

Gene names

    • Name
      TM7SF2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E9PS18

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-79Helical
Transmembrane137-155Helical
Transmembrane167-186Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 268 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Expression

Gene expression databases

Structure

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,781
  • Last updated
    2011-04-05 v1
  • Checksum
    79DF0E0C25FD2AEE
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKL

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O76062ERG24_HUMANTM7SF2418
H0YDY5H0YDY5_HUMANTM7SF293
H0YEN6H0YEN6_HUMANTM7SF2208
H0YCI8H0YCI8_HUMANTM7SF2181
E9PS09E9PS09_HUMANTM7SF2256
E9PRQ1E9PRQ1_HUMANTM7SF2223
E9PQ50E9PQ50_HUMANTM7SF2148
E9PQZ7E9PQZ7_HUMANTM7SF2115
E9PP79E9PP79_HUMANTM7SF2135
E9PLS9E9PLS9_HUMANTM7SF2271
E9PLI3E9PLI3_HUMANTM7SF2292
E9PLL1E9PLL1_HUMANTM7SF2207
E9PK81E9PK81_HUMANTM7SF289

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue219

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP003068
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp