E9PS18 · E9PS18_HUMAN
- ProteinDelta(14)-sterol reductase TM7SF2
- GeneTM7SF2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids219 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H+ + NADPH
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + H+ + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + H+ + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase TM7SF2
- EC number
- Short namesDelta-14-SR
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE9PS18
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-79 | Helical | ||||
Sequence: PRALLLWLAWLGLQAALYLL | ||||||
Transmembrane | 137-155 | Helical | ||||
Sequence: FGFMLAFGDMAWVPFTYSL | ||||||
Transmembrane | 167-186 | Helical | ||||
Sequence: LGLPMASVICLINATGYYIF |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 268 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,781
- Last updated2011-04-05 v1
- Checksum79DF0E0C25FD2AEE
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O76062 | ERG24_HUMAN | TM7SF2 | 418 | ||
H0YDY5 | H0YDY5_HUMAN | TM7SF2 | 93 | ||
H0YEN6 | H0YEN6_HUMAN | TM7SF2 | 208 | ||
H0YCI8 | H0YCI8_HUMAN | TM7SF2 | 181 | ||
E9PS09 | E9PS09_HUMAN | TM7SF2 | 256 | ||
E9PRQ1 | E9PRQ1_HUMAN | TM7SF2 | 223 | ||
E9PQ50 | E9PQ50_HUMAN | TM7SF2 | 148 | ||
E9PQZ7 | E9PQZ7_HUMAN | TM7SF2 | 115 | ||
E9PP79 | E9PP79_HUMAN | TM7SF2 | 135 | ||
E9PLS9 | E9PLS9_HUMAN | TM7SF2 | 271 | ||
E9PLI3 | E9PLI3_HUMAN | TM7SF2 | 292 | ||
E9PLL1 | E9PLL1_HUMAN | TM7SF2 | 207 | ||
E9PK81 | E9PK81_HUMAN | TM7SF2 | 89 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 219 | |||||
Sequence: L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP003068 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |