E9PPF9 · E9PPF9_HUMAN

  • Protein
    Mitochondrial fission regulator
  • Gene
    MTFR1L
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels.
Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrion
Biological Processaerobic respiration
Biological Processmitochondrial fission

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial fission regulator

Gene names

    • Name
      MTFR1L

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E9PPF9

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion outer membrane
; Peripheral membrane protein

Keywords

Disease & Variants

Variants

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The viewer provides 126 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)6PRIDEPhosphoserine
Modified residue (large scale data)13PRIDEPhosphoserine
Modified residue (large scale data)126PRIDEPhosphoserine
Modified residue (large scale data)127PRIDEPhosphoserine
Modified residue (large scale data)128PRIDEPhosphoserine
Modified residue (large scale data)135PRIDEPhosphoserine
Modified residue (large scale data)137PRIDEPhosphoserine
Modified residue (large scale data)140PRIDEPhosphoserine
Modified residue (large scale data)141PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Sequence similarities

Belongs to the MTFR1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    160
  • Mass (Da)
    17,141
  • Last updated
    2011-04-05 v1
  • Checksum
    944F536D328D9AEC
MQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQD

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9H019MFR1L_HUMANMTFR1L292
C9JF50C9JF50_HUMANMTFR1L152
E9PRK5E9PRK5_HUMANMTFR1L182
E9PRW1E9PRW1_HUMANMTFR1L110
E9PSD6E9PSD6_HUMANMTFR1L115
E9PPQ0E9PPQ0_HUMANMTFR1L53
E9PNJ0E9PNJ0_HUMANMTFR1L13
E9PLD2E9PLD2_HUMANMTFR1L195
E9PLU1E9PLU1_HUMANMTFR1L170
E9PJP7E9PJP7_HUMANMTFR1L73
E9PIF9E9PIF9_HUMANMTFR1L52

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue160

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL020996
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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