E9PKE3 · E9PKE3_HUMAN

  • Protein
    Heat shock cognate 71 kDa protein
  • Gene
    HSPA8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentspliceosomal complex
Molecular FunctionATP binding
Molecular FunctionATP-dependent protein folding chaperone
Biological Processclathrin coat disassembly
Biological ProcessmRNA processing
Biological ProcessRNA splicing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heat shock cognate 71 kDa protein
  • EC number
  • Alternative names
    • Heat shock 70 kDa protein 8

Gene names

    • Name
      HSPA8

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E9PKE3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 509 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)2PRIDEPhosphoserine
Modified residue (large scale data)15PRIDEPhosphotyrosine
Modified residue (large scale data)40PRIDEPhosphoserine
Modified residue (large scale data)41PRIDEPhosphotyrosine
Modified residue (large scale data)45PRIDEPhosphothreonine
Modified residue (large scale data)85PRIDEPhosphoserine
Modified residue (large scale data)107PRIDEPhosphotyrosine
Modified residue (large scale data)111PRIDEPhosphothreonine
Modified residue (large scale data)158PRIDEPhosphothreonine
Modified residue (large scale data)202PRIDEPhosphoserine
Modified residue (large scale data)203PRIDEPhosphothreonine
Modified residue (large scale data)207PRIDEPhosphothreonine
Modified residue (large scale data)310PRIDEPhosphoserine
Modified residue (large scale data)343PRIDEPhosphoserine
Modified residue (large scale data)399PRIDEPhosphothreonine
Modified residue (large scale data)412PRIDEPhosphotyrosine
Modified residue (large scale data)492PRIDEPhosphoserine
Modified residue (large scale data)522PRIDEPhosphoserine
Modified residue (large scale data)525PRIDEPhosphoserine
Modified residue (large scale data)614PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region595-627Disordered

Sequence similarities

Belongs to the heat shock protein 70 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    627
  • Mass (Da)
    68,806
  • Last updated
    2011-04-05 v1
  • MD5 Checksum
    ED7D2C3C4AC5FFCD9F5CFDDA025AF3BC
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P11142HSP7C_HUMANHSPA8646
E9PS65E9PS65_HUMANHSPA8223
E9PPY6E9PPY6_HUMANHSPA8137
E9PQK7E9PQK7_HUMANHSPA8178
E9PQQ4E9PQQ4_HUMANHSPA8171
E9PNE6E9PNE6_HUMANHSPA8500
E9PN89E9PN89_HUMANHSPA8312
E9PM13E9PM13_HUMANHSPA8150
E9PLF4E9PLF4_HUMANHSPA8187
E9PN25E9PN25_HUMANHSPA8132
E9PK54E9PK54_HUMANHSPA8183
A8K7Q2A8K7Q2_HUMANHSPA8410
E9PI65E9PI65_HUMANHSPA8168

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP000926
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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