E9PEW0 · E9PEW0_HUMAN
- ProteinUbiquitin carboxyl-terminal hydrolase
- GeneUSP36
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids548 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear speck | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | cysteine-type deubiquitinase activity | |
Biological Process | nucleolus organization | |
Biological Process | protein deubiquitination | |
Biological Process | protein stabilization | |
Biological Process | proteolysis | |
Biological Process | regulation of rRNA processing |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin carboxyl-terminal hydrolase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE9PEW0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,424 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 18 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 429 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 439 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 463 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 464 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 513 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 515 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 521 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MPIVDKLKEALKPGRKDSADDG | ||||||
Region | 67-95 | Disordered | ||||
Sequence: TEGASRHKSGDDPPARRQGSEHTYESCGD | ||||||
Compositional bias | 70-89 | Basic and acidic residues | ||||
Sequence: ASRHKSGDDPPARRQGSEHT | ||||||
Domain | 122-423 | USP | ||||
Sequence: AGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRI | ||||||
Region | 430-548 | Disordered | ||||
Sequence: PEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPLPTGMG | ||||||
Compositional bias | 432-446 | Polar residues | ||||
Sequence: GLISRTGSSSLPGRP | ||||||
Compositional bias | 457-471 | Polar residues | ||||
Sequence: IGNGIISSPLTGKRQ | ||||||
Compositional bias | 487-501 | Polar residues | ||||
Sequence: VPISRNGSTLGLKSQ |
Sequence similarities
Belongs to the peptidase C19 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length548
- Mass (Da)60,304
- Last updated2014-10-29 v2
- Checksum02ECE1A35D971C74
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9P275 | UBP36_HUMAN | USP36 | 1123 | ||
A0A075B784 | A0A075B784_HUMAN | USP36 | 716 | ||
A0A8I5QJW4 | A0A8I5QJW4_HUMAN | USP36 | 158 | ||
K7EIH0 | K7EIH0_HUMAN | USP36 | 101 | ||
K7EJI3 | K7EJI3_HUMAN | USP36 | 52 | ||
K7EIT7 | K7EIT7_HUMAN | USP36 | 24 | ||
Q8IXW9 | Q8IXW9_HUMAN | USP36 | 285 | ||
U3KQ92 | U3KQ92_HUMAN | USP36 | 61 | ||
K7EKL7 | K7EKL7_HUMAN | USP36 | 71 | ||
K7EKN3 | K7EKN3_HUMAN | USP36 | 69 | ||
K7EMM6 | K7EMM6_HUMAN | USP36 | 259 | ||
K7ELR5 | K7ELR5_HUMAN | USP36 | 234 | ||
K7ELT3 | K7ELT3_HUMAN | USP36 | 80 | ||
K7EPT1 | K7EPT1_HUMAN | USP36 | 179 | ||
K7EQS0 | K7EQS0_HUMAN | USP36 | 159 | ||
K7ERP8 | K7ERP8_HUMAN | USP36 | 11 | ||
K7ERC1 | K7ERC1_HUMAN | USP36 | 66 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 70-89 | Basic and acidic residues | ||||
Sequence: ASRHKSGDDPPARRQGSEHT | ||||||
Compositional bias | 432-446 | Polar residues | ||||
Sequence: GLISRTGSSSLPGRP | ||||||
Compositional bias | 457-471 | Polar residues | ||||
Sequence: IGNGIISSPLTGKRQ | ||||||
Compositional bias | 487-501 | Polar residues | ||||
Sequence: VPISRNGSTLGLKSQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC022966 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |