E9M0G2 · E9M0G2_MOUSE
- ProteinLeptin
- GeneLep
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids167 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for E9M0G2
The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3.
- CategoriesFunction, Interaction
- SourceMGI: 104663
A role for calcium in resistin transcriptional activation in diabetic hearts.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis.
- CategoriesFunction, Interaction
- SourceMGI: 104663
PGC-1alpha functions as a co-suppressor of XBP1s to regulate glucose metabolism.
- CategoriesFunction, Interaction
- SourceMGI: 104663
PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.
- CategoriesFunction, Interaction
- SourceMGI: 104663
WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARgamma activity.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARgamma2.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
- CategoriesFunction, Interaction
- SourceMGI: 104663
FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3.
- AnnotationData suggest FoxO1 (forkhead box O1) 140-160 (Gln145 Arg147 Lys148 Arg153 Arg154) is critical for FoxO1-Stat3 (signal transducer/activator of transcription 3) interaction/down-regulation of Lep-induced Pomc (pro-opiomelanocortin) transcription.
- CategoriesInteraction
Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Leptin modulates autophagy in human CD4+CD25- conventional T cells.
- CategoriesInteraction
- SourceMGI: 104663
Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Tob2 inhibits peroxisome proliferator-activated receptor gamma2 expression by sequestering Smads and C/EBPalpha during adipocyte differentiation.
- CategoriesFunction, Interaction
- SourceMGI: 104663
Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23.
- CategoriesInteraction
- SourceMGI: 104663
A unique FGF23 with the ability to activate FGFR signaling through both alphaKlotho and betaKlotho.
- CategoriesInteraction
- SourceMGI: 104663
Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling.
- CategoriesFunction, Interaction, Subcellular Location
- SourceMGI: 104663