E9KIQ7 · E9KIQ7_ORYSJ

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

121620406080100120140160180200
TypeIDPosition(s)Description
Active site101
Active site101Nucleophile
Active site126

GO annotations

AspectTerm
Cellular Componentchloroplast stroma
Molecular FunctionATP-dependent peptidase activity
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP

Encoded on

  • Chloroplast

Organism names

  • Taxonomic identifier
  • Strain
    • 317387
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    E9KIQ7

Subcellular Location

Keywords

Interaction

Subunit

Component of the chloroplastic Clp protease core complex.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    24,728
  • Last updated
    2011-04-05 v1
  • MD5 Checksum
    4B6DC6854B3FAC0918089CD348A1C5FA
MPIGVPKVPYRIPGDEEATWVDLYNVMYRERTLFLGQEIRCEVTNHITGLMVYLSIEDGISDIFLFINSPGGWLISGMAIFDTMQTVTPDIYTICLGIAASMASFILLGGEPTKRIAFPHARIMLHQPASAYYRARTPEFLLEVEELHKVREMITRVYALRTGKPFWVVSEDMERDVFMSADEAKAYGLVDIVGDEMLDEHCDTDPVWFPEMFKDW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU592207
EMBL· GenBank· DDBJ
ADD62850.1
EMBL· GenBank· DDBJ
Genomic DNA
KM088016
EMBL· GenBank· DDBJ
AJC99338.1
EMBL· GenBank· DDBJ
Genomic DNA
KM088017
EMBL· GenBank· DDBJ
AJC99427.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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