Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

E9K9H1 · E9K9H1_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB
    • Synonyms
      cytb

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DH003
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E9K9H1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-308Helical
Transmembrane320-339Helical
Transmembrane345-372Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,730
  • Last updated
    2011-04-05 v1
  • MD5 Checksum
    45023F2D4DD4981E059B222815037218
MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMTTAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ337670
EMBL· GenBank· DDBJ
ACU11288.1
EMBL· GenBank· DDBJ
Genomic DNA
GU480015
EMBL· GenBank· DDBJ
ADD32207.1
EMBL· GenBank· DDBJ
Genomic DNA
GU480019
EMBL· GenBank· DDBJ
ADD32259.1
EMBL· GenBank· DDBJ
Genomic DNA
GU480020
EMBL· GenBank· DDBJ
ADD32272.1
EMBL· GenBank· DDBJ
Genomic DNA
GU480021
EMBL· GenBank· DDBJ
ADD32285.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012205
EMBL· GenBank· DDBJ
ADM60618.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012213
EMBL· GenBank· DDBJ
ADM60722.1
EMBL· GenBank· DDBJ
Genomic DNA
JN253410
EMBL· GenBank· DDBJ
AEM55089.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ245739
EMBL· GenBank· DDBJ
AEY71060.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ245740
EMBL· GenBank· DDBJ
AEY71073.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702534
EMBL· GenBank· DDBJ
AFF70912.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702595
EMBL· GenBank· DDBJ
AFF71705.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705570
EMBL· GenBank· DDBJ
AFG10380.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705943
EMBL· GenBank· DDBJ
AFG15229.1
EMBL· GenBank· DDBJ
Genomic DNA
KC533494
EMBL· GenBank· DDBJ
AGK64672.1
EMBL· GenBank· DDBJ
Genomic DNA
KC867119
EMBL· GenBank· DDBJ
AGO01649.1
EMBL· GenBank· DDBJ
Genomic DNA
KF056281
EMBL· GenBank· DDBJ
AGT52852.1
EMBL· GenBank· DDBJ
Genomic DNA
KF644562
EMBL· GenBank· DDBJ
AGW45366.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451207
EMBL· GenBank· DDBJ
AGZ69336.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451640
EMBL· GenBank· DDBJ
AGZ74965.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451791
EMBL· GenBank· DDBJ
AGZ76928.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451794
EMBL· GenBank· DDBJ
AGZ76967.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ445943
EMBL· GenBank· DDBJ
AHX45325.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446120
EMBL· GenBank· DDBJ
AHX47626.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446402
EMBL· GenBank· DDBJ
AHX51292.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446403
EMBL· GenBank· DDBJ
AHX51305.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101928
EMBL· GenBank· DDBJ
AIU61775.1
EMBL· GenBank· DDBJ
Genomic DNA
KP419690
EMBL· GenBank· DDBJ
AJE60827.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587392
EMBL· GenBank· DDBJ
AMZ80901.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587395
EMBL· GenBank· DDBJ
AMZ80940.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587396
EMBL· GenBank· DDBJ
AMZ80953.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587398
EMBL· GenBank· DDBJ
AMZ80979.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587413
EMBL· GenBank· DDBJ
AMZ81174.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587473
EMBL· GenBank· DDBJ
AMZ81954.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587537
EMBL· GenBank· DDBJ
AMZ82786.1
EMBL· GenBank· DDBJ
Genomic DNA
KT587643
EMBL· GenBank· DDBJ
AMZ84164.1
EMBL· GenBank· DDBJ
Genomic DNA
KX146834
EMBL· GenBank· DDBJ
AOP04421.1
EMBL· GenBank· DDBJ
Genomic DNA
KY595611
EMBL· GenBank· DDBJ
ARD72579.1
EMBL· GenBank· DDBJ
Genomic DNA
KY680948
EMBL· GenBank· DDBJ
ASZ82425.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272847
EMBL· GenBank· DDBJ
AVL88443.1
EMBL· GenBank· DDBJ
Genomic DNA
MK049277
EMBL· GenBank· DDBJ
AYN80983.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449150
EMBL· GenBank· DDBJ
AYW06671.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449158
EMBL· GenBank· DDBJ
AYW06775.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449167
EMBL· GenBank· DDBJ
AYW06892.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449170
EMBL· GenBank· DDBJ
AYW06931.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449172
EMBL· GenBank· DDBJ
AYW06957.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449173
EMBL· GenBank· DDBJ
AYW06970.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449175
EMBL· GenBank· DDBJ
AYW06996.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449178
EMBL· GenBank· DDBJ
AYW07035.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449180
EMBL· GenBank· DDBJ
AYW07061.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449237
EMBL· GenBank· DDBJ
AYW07802.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449241
EMBL· GenBank· DDBJ
AYW07854.1
EMBL· GenBank· DDBJ
Genomic DNA
MH553841
EMBL· GenBank· DDBJ
QBY38840.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849687
EMBL· GenBank· DDBJ
QKT24477.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849697
EMBL· GenBank· DDBJ
QKT24607.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849707
EMBL· GenBank· DDBJ
QKT24737.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849710
EMBL· GenBank· DDBJ
QKT24776.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849712
EMBL· GenBank· DDBJ
QKT24802.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849713
EMBL· GenBank· DDBJ
QKT24815.1
EMBL· GenBank· DDBJ
Genomic DNA
MN628028
EMBL· GenBank· DDBJ
QXO90938.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help