E9K9H1 · E9K9H1_HUMAN
- ProteinCytochrome b
- GeneCYTB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE9K9H1
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 30-56 | Helical | |||
Transmembrane | 77-98 | Helical | |||
Transmembrane | 113-133 | Helical | |||
Transmembrane | 140-158 | Helical | |||
Transmembrane | 178-200 | Helical | |||
Transmembrane | 229-246 | Helical | |||
Transmembrane | 288-308 | Helical | |||
Transmembrane | 320-339 | Helical | |||
Transmembrane | 345-372 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | |||
Domain | 210-380 | Cytochrome b/b6 C-terminal region profile | |||
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,730
- Last updated2011-04-05 v1
- MD5 Checksum45023F2D4DD4981E059B222815037218
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GQ337670 EMBL· GenBank· DDBJ | ACU11288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU480015 EMBL· GenBank· DDBJ | ADD32207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU480019 EMBL· GenBank· DDBJ | ADD32259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU480020 EMBL· GenBank· DDBJ | ADD32272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU480021 EMBL· GenBank· DDBJ | ADD32285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012205 EMBL· GenBank· DDBJ | ADM60618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012213 EMBL· GenBank· DDBJ | ADM60722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN253410 EMBL· GenBank· DDBJ | AEM55089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ245739 EMBL· GenBank· DDBJ | AEY71060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ245740 EMBL· GenBank· DDBJ | AEY71073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702534 EMBL· GenBank· DDBJ | AFF70912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702595 EMBL· GenBank· DDBJ | AFF71705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705570 EMBL· GenBank· DDBJ | AFG10380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705943 EMBL· GenBank· DDBJ | AFG15229.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC533494 EMBL· GenBank· DDBJ | AGK64672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC867119 EMBL· GenBank· DDBJ | AGO01649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF056281 EMBL· GenBank· DDBJ | AGT52852.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF644562 EMBL· GenBank· DDBJ | AGW45366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451207 EMBL· GenBank· DDBJ | AGZ69336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451640 EMBL· GenBank· DDBJ | AGZ74965.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451791 EMBL· GenBank· DDBJ | AGZ76928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451794 EMBL· GenBank· DDBJ | AGZ76967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ445943 EMBL· GenBank· DDBJ | AHX45325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446120 EMBL· GenBank· DDBJ | AHX47626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446402 EMBL· GenBank· DDBJ | AHX51292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446403 EMBL· GenBank· DDBJ | AHX51305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101928 EMBL· GenBank· DDBJ | AIU61775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP419690 EMBL· GenBank· DDBJ | AJE60827.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587392 EMBL· GenBank· DDBJ | AMZ80901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587395 EMBL· GenBank· DDBJ | AMZ80940.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587396 EMBL· GenBank· DDBJ | AMZ80953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587398 EMBL· GenBank· DDBJ | AMZ80979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587413 EMBL· GenBank· DDBJ | AMZ81174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587473 EMBL· GenBank· DDBJ | AMZ81954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587537 EMBL· GenBank· DDBJ | AMZ82786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT587643 EMBL· GenBank· DDBJ | AMZ84164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX146834 EMBL· GenBank· DDBJ | AOP04421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595611 EMBL· GenBank· DDBJ | ARD72579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY680948 EMBL· GenBank· DDBJ | ASZ82425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272847 EMBL· GenBank· DDBJ | AVL88443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK049277 EMBL· GenBank· DDBJ | AYN80983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449150 EMBL· GenBank· DDBJ | AYW06671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449158 EMBL· GenBank· DDBJ | AYW06775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449167 EMBL· GenBank· DDBJ | AYW06892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449170 EMBL· GenBank· DDBJ | AYW06931.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449172 EMBL· GenBank· DDBJ | AYW06957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449173 EMBL· GenBank· DDBJ | AYW06970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449175 EMBL· GenBank· DDBJ | AYW06996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449178 EMBL· GenBank· DDBJ | AYW07035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449180 EMBL· GenBank· DDBJ | AYW07061.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449237 EMBL· GenBank· DDBJ | AYW07802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449241 EMBL· GenBank· DDBJ | AYW07854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553841 EMBL· GenBank· DDBJ | QBY38840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849687 EMBL· GenBank· DDBJ | QKT24477.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849697 EMBL· GenBank· DDBJ | QKT24607.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849707 EMBL· GenBank· DDBJ | QKT24737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849710 EMBL· GenBank· DDBJ | QKT24776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849712 EMBL· GenBank· DDBJ | QKT24802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849713 EMBL· GenBank· DDBJ | QKT24815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN628028 EMBL· GenBank· DDBJ | QXO90938.1 EMBL· GenBank· DDBJ | Genomic DNA |