E9JFX9 · DMOA_HYPSL

Function

function

Monooxygenase that mediates oxidation of dimethyl sulfide, the first step in dimethyl sulfide degradation pathway. Has much lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides.

Miscellaneous

DmoB has not been identified yet. Only a peptide from the protein encoded by a putative flavin reductase (AC E0XCR3) was obtained by mass spectrometry, which is insufficient for linking this gene to DmoB (PubMed:21216999).

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Activity regulation

Inhibited by umbelliferone, 8-anilinonaphthalenesulfonate, a range of metal-chelating agents, and Hg2+, Cd2+ and Pb2+ ions.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
17.2 μMDimethyl sulfide
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
1.25 μmol/min/mg

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site58FMN (UniProtKB | ChEBI)
Binding site104FMN (UniProtKB | ChEBI)
Binding site154FMN (UniProtKB | ChEBI)
Binding site158FMN (UniProtKB | ChEBI)
Binding site230FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondimethyl sulfide monooxygenase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dimethyl-sulfide monooxygenase
  • EC number
  • Alternative names
    • Dimethylsulfide monooxygenase large subunit

Gene names

    • Name
      dmoA

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC BAA-113 / DSM 13863 / S1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Hyphomicrobiaceae > Hyphomicrobium

Accessions

  • Primary accession
    E9JFX9

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004189291-480Dimethyl-sulfide monooxygenase

Interaction

Subunit

Heterodimer of 2 subunits, DmoA and DmoB.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region423-480Disordered

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    53,116
  • Last updated
    2011-04-05 v1
  • Checksum
    0AEC2DE5548A33FF
MKKRIVLNAFDMTCVSHQSAGTWRHPSSQAARYNDLEYWTNMAMELERGCFDCLFIADVVGVYDVYRGSAEMALRDADQVPVNDPFGAISAMAAVTEHVGFGVTAAITFEQPYLLARRLSTLDHLTKGRVAWNVVSSYLNSAALNIGMDQQLAHDERYEMADEYMEVMYKLWEGSWEDDAVKRDKKSGVFTDGSKVHPINHQGKYYKVPGFHICEPSPQRTPVIFQAGASGRGSKFAASNAEGMFILTTSVEQARQITTDIRNQAEAAGRSRDSIKIFMLLTVITGDSDEAAEAKYQEYLSYANPEGMLALYGGWTGIDFAKLDPDEPLQAMENDSLRTTLESLTHGENAKKWTVRDVIRERCIGGLGPVLVGGPQKVADELERWVDEGGVDGFNLAYAVTPGSVTDFIDYIVPELRKRGRAQDSYKPGSLRRKLIGTNDGRVESTHPAAQYRDAYVGKESVADRTQPSPFANAKAPVAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ980036
EMBL· GenBank· DDBJ
ADU77278.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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