E9HGT0 · E9HGT0_DAPPU

  • Protein
    O-phosphoseryl-tRNA(Sec) selenium transferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site74May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Binding site75pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site97substrate
Binding site98substrate
Binding site105substrate
Binding site271tRNA (UniProtKB | ChEBI)
Binding site313substrate
Binding site396tRNA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionO-phosphoseryl-tRNA(Sec) selenium transferase activity
Molecular FunctiontRNA binding
Biological Processconversion of seryl-tRNAsec to selenocys-tRNAsec
Biological Processselenocysteine incorporation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    O-phosphoseryl-tRNA(Sec) selenium transferase
  • EC number
  • Alternative names
    • Selenocysteine synthase
    • Selenocysteinyl-tRNA(Sec) synthase
    • Sep-tRNA:Sec-tRNA synthase

Gene names

    • ORF names
      DAPPUDRAFT_301202

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Branchiopoda > Diplostraca > Cladocera > Anomopoda > Daphniidae > Daphnia

Accessions

  • Primary accession
    E9HGT0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue284N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the SepSecS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    497
  • Mass (Da)
    54,926
  • Last updated
    2011-04-05 v1
  • Checksum
    998F4BEE4877307A
MDDTSFKLLAKYLPSTYVQQAKDARNSQNFLINQLLEKRKWPEEGWSDRSIEMLLDELASLDSNNFIKNRGVGEREARIASSLVARRNFHLGHGLGRSGDLTEVQPKAAGSSVMYQLTNDLAKDALRTLGVPGIQACFVAPLATGMSLTLIFLTLRQQKPKAKYIIWSRIDQKSCFKSIITAGFEPIIVQTVLDGDELVTDSGKIEAIIKQTDPELIACVMTTTSCFAPRACDDVESVAVICKNHNIAHVINNAYGVQNTKCMHVIQQASKKGRVDAFVQSTDKNFMVPVGGTIIAGFDKLFINKVSQCYPGRASSSPIIDLFITLLSLGSKEYISLVKERKQLYQSLKEGLVKVASQFGQRILHTPGNSISIGISLPPLQDPKILTQLGSQLFLRCVSGTRVVSNLEHKVINDHEFRSWGSHHNKYPTAYLTAAATIGMTPVDVEQFLHRLTKVLESWSAKIAPIAVPLLTNGHEVFAHDLLLTDEYLVDQESSVI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL732643
EMBL· GenBank· DDBJ
EFX69063.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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