E9FTK6 · E9FTK6_DAPPU
- ProteinPhosphatidylserine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids444 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
Catalytic activity
- 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamineThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamineThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylserine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity | |
Biological Process | phosphatidylserine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylserine synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Branchiopoda > Diplostraca > Cladocera > Anomopoda > Daphniidae > Daphnia
Accessions
- Primary accessionE9FTK6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 65-88 | Helical | ||||
Sequence: FFWRAHTLTVLFVMIAALIYVAVF | ||||||
Transmembrane | 100-118 | Helical | ||||
Sequence: KRGLVACVVVFILLCATVT | ||||||
Transmembrane | 130-150 | Helical | ||||
Sequence: LWRFTFSLSIVYELVLIFVLF | ||||||
Transmembrane | 220-237 | Helical | ||||
Sequence: WWLCTIISIMFEILEYTL | ||||||
Transmembrane | 252-274 | Helical | ||||
Sequence: WIMDALLCNGLGIIIGIQTLKYF | ||||||
Transmembrane | 320-339 | Helical | ||||
Sequence: WCATLGIMFIFLLTELNTFY | ||||||
Transmembrane | 351-368 | Helical | ||||
Sequence: WLNLVRLFLVLLWGAVAL | ||||||
Transmembrane | 388-406 | Helical | ||||
Sequence: WVILSIVITEFLIVARFDW | ||||||
Transmembrane | 418-438 | Helical | ||||
Sequence: VLFWSIFFLLLLTWTVFRFFI |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-29 | Disordered | ||||
Sequence: MGSAGLEENEKSPTKKQANKKNFVKEASP | ||||||
Compositional bias | 9-29 | Basic and acidic residues | ||||
Sequence: NEKSPTKKQANKKNFVKEASP |
Sequence similarities
Belongs to the phosphatidyl serine synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)52,313
- Last updated2011-04-05 v1
- Checksum79E4A48FA1CF4BFC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 9-29 | Basic and acidic residues | ||||
Sequence: NEKSPTKKQANKKNFVKEASP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GL732524 EMBL· GenBank· DDBJ | EFX89379.1 EMBL· GenBank· DDBJ | Genomic DNA |