Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

E9FBQ6 · E9FBQ6_METRA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.
    EC:3.4.24.39 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

160050100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site177Zn2+ (UniProtKB | ChEBI); catalytic
Active site178
Binding site181Zn2+ (UniProtKB | ChEBI); catalytic
Binding site190Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    deuterolysin
  • EC number

Gene names

    • ORF names
      MAA_09705

Organism names

Accessions

  • Primary accession
    E9FBQ6

Proteomes

Subcellular Location

Secreted

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_500718975018-600deuterolysin

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain74-218Lysine-specific metallo-endopeptidase
Compositional bias340-361Polar residues
Region340-365Disordered
Region459-489Disordered

Sequence similarities

Belongs to the peptidase M35 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    600
  • Mass (Da)
    64,389
  • Last updated
    2011-04-05 v1
  • MD5 Checksum
    7C1DD31567C8D43930715361A735A5EB
MKFSSLILFSGATLAAALAPPIPPGQGAAVGTSPRSNTHSYLKARAKVDPKCDSKQKKDIKKALDVCRKIAKAAAAAARTGDAARLETYFHTSDQAFRNRIATLYDDIAQECKDGKDGLLTISCDAADAQCPNPEDPNTVAYFTRGTDTVTLCPAALARPVKPKRCGERSLAGVLIHEFSHALSSSLVVDHRYGRFESTQLTRDQALGNADTFQWFAIDAYLNCPAPTADSPPTSEPVAGPSGLCQQHVSKALEPTRAKSKGKKLLLSEVVPDVQQALCTARPADQPPANTATDATRCNEGVSELLQVFDEVPENELSEYLASEDIVKDMCFEPSVHNNMPGFASDQDGLNETQPPTEPAPELDQSSWPRFVEQVQQQFNIAEQQLRTYLDAGIQSLQQNYPQVYRLLERTFPLAINVLREMATAQIRFTSCLPDKPRSSRRLKARADQDVCKKVLAAIGQPAPAGSPPDKTPPSTTPPSEQKDSEDSTTLAVAIGVPVTAVTVAFFTTGDGAALIASVATSLGISTEVGSVAEAVTAALSRVTSSLTQVTRQAVQRIIGRVSRLGHRVANPLLRQITSRALRSATARASERIPLLSFSG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias340-361Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADNJ02000002
EMBL· GenBank· DDBJ
EFY94875.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help