E9FB59 · E9FB59_METRA

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site104L-glutamate (UniProtKB | ChEBI)
Active site377Nucleophile
Binding site395-397L-glutamate (UniProtKB | ChEBI)
Binding site419L-glutamate (UniProtKB | ChEBI)
Binding site470L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionglutathione hydrolase activity
Molecular Functionleukotriene C4 gamma-glutamyl transferase activity
Biological Processglutathione catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • ORF names
      MAA_09508

Organism names

Accessions

  • Primary accession
    E9FB59

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_500323982225-567Glutathione hydrolase

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    567
  • Mass (Da)
    61,736
  • Last updated
    2015-03-04 v2
  • Checksum
    BF807A7018557214
MLFNITKILNYLLLIASTPTIVYGEEQNYGTNHGAVASESKICSEIGTQLLQKCHGGRCGNAVDALVGTVFCVGTVAMYHSGIGGGGFALVRLPNGTYKSVDFREVAPDAAHENMYQGNIDGSKIGGLASAVPGEVKGLKYIHENYGNLRWADVMAPAIKLARYGFPVSKDLVTYMDLTTPNSFFTDEKEWAIDFAPQGHRVRYGEIMTRERYANTLEDIANRGPKAFYTGHIAEATIRALKSRNGCMELEDLERYNFTLPDPVKIQYRDYSLTSINAPSSGIVALSALNILGGFLDFEEPRQSNSSTHRMIEAIKWGYGQRKGLGDPSFVALGQYTKNMISKETGDWIRSKISDNQTFDDDYYDVDGTELLKTPGTSHIVTADASGMSVSMTTTINLYFGSHVMVPETGVIMNNEMNDFDIPSERNRFGLDSNKANFIQGRKRPLSAISPIIAETSDNKLLFSIGCAGGIRITTANIQNAIHLLDGKMTTLEALSEPRLHAQLGQARNVTIEGGYDNGVIGFLESLGHGINRGPAQTSAQGLRRLPDGSFEAAAEPRQCNSGASVV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADNJ02000004
EMBL· GenBank· DDBJ
EFY95059.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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