E9EDV3 · E9EDV3_METAQ

Function

function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Cofactor

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionoxoglutarate dehydrogenase (succinyl-transferring) activity
Molecular Functionthiamine pyrophosphate binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-oxoglutarate dehydrogenase, mitochondrial
  • EC number
  • Alternative names
    • 2-oxoglutarate dehydrogenase complex component E1

Gene names

    • ORF names
      MAC_08058

Organism names

  • Taxonomic identifier
  • Strain
    • CQMa 102
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium

Accessions

  • Primary accession
    E9EDV3

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain671-881Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,049
  • Mass (Da)
    118,517
  • Last updated
    2011-04-05 v1
  • Checksum
    5C29AACDF3B814E7
MLRNPLCRASSQVLRGARCSAALSRSSIPTVSARTSSWKLAAVRRPLAATAARSYATDALHSPPDPSDNFLSGGAANYIDEMYMQWKQDPKSVHVSWQVYFKNMESGDMPISQAFQPPPNLVPNMTGGVPRLAGNLALEDGSDVTNHLKVQLLVRAYQARGHHKANIDPLGIRNTAEGFGNIKPKELTLEHYGFTEADLDTEYTLGPGILPRFKREGRDKMTLREIVAACERIYAGSWGVEFIHIPDREKCDWLRERLEVPQPFKYSIDEKRRVLDRLIWSSSFESFLATKYPNDKRFGLEGCETLVPGMKALIDRSVDYGVKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGTLGAEDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRAIQHYNNDEKTHRTAMGVLLHGDAAFAAQGIVYECLGFHSLPAFSTGGTIHLVVNNQIGFTTDPRFARSTAYCTDIAKAIDAPVFHVNADDVEAVNFVCQLAADWRAEFQHDVVIDLICYRKHGHNETDQPSFTQPLMYKRIQQKEPQIDVYVNKLLREGTFTKEDIEEHKQWVWGMLEESFDKSKDYTPTSKEWTTSAWNGFKSPKELATEILPHHATGVDRKTLDHVGEVIGSAPEGFQIHRNLKRILTNRTKSVVEGKNIDFPTAEALAFGSLVTEGYHVRVSGQDVERGTFSQRHAVFHEQENEKTYTPLQHISKDQGKFVISNSSLSEFGALGFEYGYSLQSPNALVMWEAQFGDFANNAQCIIDQFIASGEVKWMQRTGLIMSLPHGYDGQGPEHSSGRLERYLQLSNEDPRIFPTEEKLARQHQDCNMQIAYMTTPANLFHVLRRQMHRQFRKPLVIFFSKSLLRHPLARSNIEDFSGEDAGFQWIIPDPEHQTGAIKAPEEIDRVILCTGQVWAALHKYRADNKIDNVAFTRIEQLNPFPWQQLKENLDMYPNAKTIVWAQEEPLNAGAWSFTQPRIETLLNQTKYHDRKHVMYAGRNPSASVATGAKHLHKKEEEEFLEMAFTVKQDKLKGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL698562
EMBL· GenBank· DDBJ
EFY85912.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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