E9E766 · BTPSL_METAQ

Function

function

Terpene synthase that catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) into sesquiterpenes which are important for fungi-environment interactions (PubMed:31239482).
Produces a mixture consisting of 8 sesquiterpenes including corvol ethers A and B, as well as traces of epizonarene, gamma-cadinene, delta-cadinene, alpha-cadinene, alpha-cadinol, and an unidentified sesquiterpene (PubMed:31239482).
Produces both corvol ether A and corvol ether B in similar concentrations (PubMed:31239482).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 3 Mg2+ ions per subunit.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site88Plays a critical role in the stabilization of intermediate cation
Binding site91Mg2+ 1 (UniProtKB | ChEBI)
Site92Plays a critical role for substrate recognition
Binding site96Mg2+ 1 (UniProtKB | ChEBI)
Binding site96Mg2+ 2 (UniProtKB | ChEBI)
Binding site184substrate
Binding site230Mg2+ 3 (UniProtKB | ChEBI)
Binding site234Mg2+ 3 (UniProtKB | ChEBI)
Binding site238Mg2+ 3 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Biological Processisoprenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sesquiterpene synthase MAC_05714
  • EC number
  • Alternative names
    • Bacterial terpene synthase-like protein MAC_05714
      (BTPSL
      )

Gene names

    • ORF names
      MAC_05714

Organism names

  • Taxonomic identifier
  • Strain
    • CQMa 102
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium

Accessions

  • Primary accession
    E9E766

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004510501-349Sesquiterpene synthase MAC_05714

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif91-96DDXXXD motif

Domain

The Asp-Asp-Xaa-Xaa-Xaa-Asp (DDXXXD) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similarities

Belongs to the terpene synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    349
  • Mass (Da)
    39,947
  • Last updated
    2011-04-05 v1
  • Checksum
    08EEDA1CAB36CF2D
MEKQHLKSQIAALRVPTFNIAWPERRSPKADVVEERMMKWADHHKLLVNGEYRDRVIRTRYGLLAARCYPNAGEELLQAIADYFVWFFLADDLFVDRVEVVTDETIRNLTAMIDVLDRNVAREEPVFGELAWLDVCQRLRDLLQPEAFQRFAQGMRLWATTAALQILNHQRPKSVGIREYEAIRRHTSGLNPCTSLADAANKGSVQAHEFYQPDVQKLVLQTNNIVCWANDIQSLGMEIQQPGQFRNMVTIYIQQGQSLSEAVSTTTARVNNELSDFCKLADIVTAPSISDELRVYVDGLKYWIRGYMDWVVHDTERYADKFIASDADDRCVSTLNPSLLNRSSSSATE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL698514
EMBL· GenBank· DDBJ
EFY88241.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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