E9E6S9 · PFF1_METAQ

Function

function

May be involved in vacuolar sorting and osmoregulation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site, active site, site.

110291002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site194Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site206Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site206Zn2+ 2 (UniProtKB | ChEBI); catalytic
Active site240Proton acceptor
Binding site241Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site266Zn2+ 1 (UniProtKB | ChEBI); catalytic
Site338Transition state stabilizer
Binding site339Zn2+ 2 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentvacuolar membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloexopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar membrane protease
  • EC number
  • Alternative names
    • FXNA-related family protease 1

Gene names

    • ORF names
      MAC_05577

Organism names

  • Taxonomic identifier
  • Strain
    • CQMa 102
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium

Accessions

  • Primary accession
    E9E6S9

Proteomes

Subcellular Location

Vacuole membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-11Cytoplasmic
Transmembrane12-32Helical; Name=1
Topological domain33-415Vacuolar
Transmembrane416-436Helical; Name=2
Topological domain437-469Cytoplasmic
Transmembrane470-490Helical; Name=3
Topological domain491-493Vacuolar
Transmembrane494-514Helical; Name=4
Topological domain515-532Cytoplasmic
Transmembrane533-553Helical; Name=5
Topological domain554-560Vacuolar
Transmembrane561-581Helical; Name=6
Topological domain582-698Cytoplasmic
Transmembrane699-719Helical; Name=7
Topological domain720-735Vacuolar
Transmembrane736-756Helical; Name=8
Topological domain757-763Cytoplasmic
Transmembrane764-784Helical; Name=9
Topological domain785-1029Vacuolar

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004117231-1029Vacuolar membrane protease
Glycosylation50N-linked (GlcNAc...) asparagine
Glycosylation138N-linked (GlcNAc...) asparagine
Glycosylation147N-linked (GlcNAc...) asparagine
Glycosylation937N-linked (GlcNAc...) asparagine

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region596-623Disordered
Region637-684Disordered
Compositional bias641-660Polar residues

Sequence similarities

Belongs to the peptidase M28 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,029
  • Mass (Da)
    114,089
  • Last updated
    2011-04-05 v1
  • Checksum
    B57A6C7D5E7C6634
MKLSNPFVFRPGPVSFWTTIVYLAIIIPLIYVQETVPPAPPEKDLPQGVNLTEAWLDLEVITRSYHPFNSHSNDIVRQYLVRRSRDILERNGIDYTTDLTGGVPWESRYLSSAEHPAQAAEASARPRGATLFDDRISNVTMTNPQPNDTMGRYFEGNNFYVYIHGSEDPEGDWWTSDNVQRVARNGAGVLVNCHFDSVSTGYGATDDGVACVSLLQLLSHFTSKGHQPKNGIVLLFNNAEEDGLLGAKAFGYSPLVQFCNTLVNLEGAGAGGRAMLFRTTDLEAAEAYSKSPHPFGSVVASNAFERGVIKSGTDYSVFVDNYGQRGLDIAFYSPRSRYHTEEDDARHTSVDSIWHMLSAALATTESLARTTSTKFNGPRSDGRKDLVQSGRPTAGVWFDWYGSSWSAFSLRGLFAWTLTLLITTPIVLFVVTYVLVRDDKWYFFATRVDSSVGDGEETVSFGGWKGFVRFPFALVVATALTIGSVFLLAKVNPLIIYSSGYSVWAMMLSLFYFVSWLLLRGAHFVRPSALQRGFTLIWLFIITWVLSVFAAVAEDRMNMGAVYSLAFLHTLVFAAVLISLLEQYALPAKQDFARQLSGENEEGEEQEQENLSGDGGNEQNHEDRGEADIAAAPTETTPLRADEEGQGSSEQTTTFANTYRRPVPETRGATHSGNNRKRSFPPYENEQAWSGRLPTWTWFIQLLLLVPLYVTVLGNLALVQTTSMGMTGTDGSSLLVPLMGVGILTILLLLPLTPFIHRVSHHVPLFLLLVFIGTLIYNLTAFPFSANNRFKFYFKQVVDLDKGSNVVTLNGLEKFVRPVIGSLPTPAGQRIHCDEDPFLSNLRNCQYDASLLPPDVANGEKLENLISFEASKSKNGKTVLVSLDALNTRVCFLDTSSPIFGFSVDGGAKRDDRFGSFPPEGLQQIQLWRRDWEKGWNVTLYLGGNVLPTNQDSVEATEVDEVDDDPSGGELKRRAVREFVVTARCAWSDVNSANTIPAFHEVKQFMPRWAIVAKKSVGLVEITKKIKVT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias641-660Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL698512
EMBL· GenBank· DDBJ
EFY88368.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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