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E9DGC5 · E9DGC5_COCPS

Function

function

Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine. May be involved in virulence.

Catalytic activity

  • Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.
    EC:3.4.24.39 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

135350100150200250300350
Type
IDPosition(s)Description
Binding site304Zn2+ (UniProtKB | ChEBI); catalytic
Active site305
Binding site308Zn2+ (UniProtKB | ChEBI); catalytic
Binding site319Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neutral protease 2
  • EC number
  • Alternative names
    • Deuterolysin

Gene names

    • ORF names
      CPSG_08874

Organism names

Accessions

  • Primary accession
    E9DGC5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_504055845320-353Neutral protease 2

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase M35 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    38,218
  • Last updated
    2011-04-05 v1
  • MD5 Checksum
    2DF9B6A5178DB1CBF8C6677F2CB1D10F
MLFPSIVAALAALANPVLSLTIPQATGSELDVQLSAIGNTRIKAVITNKADRQLKLLKYNNFFDDGPIQKVGVFKDGQPVKFEGMLRRVLMKNLEPSLFVSLSPGQTVEREFDIASTADLASGGAYTVFSQGAIPFAEGDGTTIAGAVAFKSNKLDLDIDGALAATVSKAINPISARTRVESACRGEQRETLLKALEYSAQLSRAAAQAAQNNTRKVEEYFMKSDAQTVETIVARLNAVAQESSSTDSGATRYFCNDRGNQCTPNTIAYTLPSLNVVVNCPIYYDLPVISDECHAQDQATTCLHEFTHNPGVYDPYCRDHAYGYDGIRKLSPEQALLNADTYSLFANAIYVNC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL636505
EMBL· GenBank· DDBJ
EFW14616.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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