Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
Mutations in SERCA disrupt Wingless signaling by sequestering Armadillo/beta-catenin away from the signaling pool. Elimination of SERCA function results in apoptosis.
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