E7RY93 · E7RY93_9BURK
- ProteinExodeoxyribonuclease I
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids489 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.
Catalytic activity
Cofactor
Note: Binds 2 Mg2+ ions per monomer.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 12 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 12 | substrate | |||
Binding site | 160 | substrate | |||
Binding site | 181 | Mg2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | single-stranded DNA 3'-5' DNA exonuclease activity | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExodeoxyribonuclease I
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Lautropia
Accessions
- Primary accessionE7RY93
Proteomes
Interaction
Subunit
Monomer. Interacts with ssb (via C-terminus); this interaction stimulates the exonuclease activity by recruiting the enzyme to its substrate.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length489
- Mass (Da)55,557
- Last updated2011-04-05 v1
- MD5 ChecksumD809D20284DA703B9A72899B245F0705
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AEQP01000013 EMBL· GenBank· DDBJ | EFV94667.1 EMBL· GenBank· DDBJ | Genomic DNA |