E7FH11 · ZD18A_DANRE
- ProteinPalmitoyltransferase ZDHHC18-A
- Genezdhhc18a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids467 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK.
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 191 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Molecular Function | palmitoyltransferase activity | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Biological Process | negative regulation of innate immune response | |
Biological Process | protein targeting to membrane |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase ZDHHC18-A
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE7FH11
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-59 | Cytoplasmic | ||||
Sequence: MKNCEYQQIDPRALRTPSSRTSSTLPCGRKGSQRLRRKWEVFPGKNRFYCDGRIMLARQ | ||||||
Transmembrane | 60-80 | Helical | ||||
Sequence: CGVLPLTIGLIFITSVLFFTF | ||||||
Topological domain | 81-88 | Lumenal | ||||
Sequence: DCPFLVDH | ||||||
Transmembrane | 89-109 | Helical | ||||
Sequence: LTVFIPVIGGVLFIFVVISLL | ||||||
Topological domain | 110-204 | Cytoplasmic | ||||
Sequence: QTSFTDPGILPRALPDEAADIEKQIDNSGSSTYRPPPRTKEILINDQVVKLKYCFTCKMFRPPRTSHCSLCDNCVERFDHHCPWVGNCVGKRNYR | ||||||
Transmembrane | 205-225 | Helical | ||||
Sequence: FFYAFIVSLSFLTSFIFGCVI | ||||||
Topological domain | 226-247 | Lumenal | ||||
Sequence: THLTLRSQGGNGFIQAIQDSPA | ||||||
Transmembrane | 248-268 | Helical | ||||
Sequence: SVVELVICFFSIWSILGLSGF | ||||||
Topological domain | 269-467 | Cytoplasmic | ||||
Sequence: HTYLVASNLTTNEDIKGSWSSKRGEESGNPYTYNNIFTNCCVVLCGPMPPSLIDRRGFVPPEDAPQTVTSDAELPAFMAKNDTNMCAQGTKELLESMANSTVIQSTCAPGKPKTAPVTQESLLNTVSITVSPPSKPPSNGCSGRQARRPIDVPCSQRGLKRAALHTHKPMLRLPSPLYSLSDSPLILSDAPDMGFIPLN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000451102 | 1-467 | Palmitoyltransferase ZDHHC18-A | |||
Sequence: MKNCEYQQIDPRALRTPSSRTSSTLPCGRKGSQRLRRKWEVFPGKNRFYCDGRIMLARQCGVLPLTIGLIFITSVLFFTFDCPFLVDHLTVFIPVIGGVLFIFVVISLLQTSFTDPGILPRALPDEAADIEKQIDNSGSSTYRPPPRTKEILINDQVVKLKYCFTCKMFRPPRTSHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYAFIVSLSFLTSFIFGCVITHLTLRSQGGNGFIQAIQDSPASVVELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGEESGNPYTYNNIFTNCCVVLCGPMPPSLIDRRGFVPPEDAPQTVTSDAELPAFMAKNDTNMCAQGTKELLESMANSTVIQSTCAPGKPKTAPVTQESLLNTVSITVSPPSKPPSNGCSGRQARRPIDVPCSQRGLKRAALHTHKPMLRLPSPLYSLSDSPLILSDAPDMGFIPLN |
Keywords
- PTM
Expression
Developmental stage
Probably maternally supplied, the zygotic expression becomes significant at 4 hpf.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 161-211 | DHHC | ||||
Sequence: KYCFTCKMFRPPRTSHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYAFIV |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length467
- Mass (Da)51,688
- Last updated2018-06-20 v3
- Checksum5C69D7ADB3E2E575
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B4S0 | A0A8M2B4S0_DANRE | zdhhc18a | 366 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 167 | in Ref. 2; AAI24361 | ||||
Sequence: K → R | ||||||
Sequence conflict | 339 | in Ref. 2; AAI24361 | ||||
Sequence: D → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX649265 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC124360 EMBL· GenBank· DDBJ | AAI24361.1 EMBL· GenBank· DDBJ | mRNA |