E7FFX0 · E7FFX0_DANRE
- ProteinA disintegrin and metalloproteinase with thrombospondin motifs 16
- Geneadamts16
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1224 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 312 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 312 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 400 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 452 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 453 | |||||
Sequence: E | ||||||
Binding site | 456 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 462 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 509 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 512 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 512 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | basement membrane disassembly | |
Biological Process | closure of optic fissure | |
Biological Process | extracellular matrix organization | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE7FFX0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 385↔436 | |||||
Sequence: CQWQSGLSGREGRRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSC | ||||||
Disulfide bond | 411↔418 | |||||
Sequence: CSWKNEPC | ||||||
Disulfide bond | 430↔509 | |||||
Sequence: CSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSVGNIMSPTLAGHNGLFSWSSCSRQYLNRFLSSAQATC | ||||||
Disulfide bond | 469↔493 | |||||
Sequence: CKKSVGNIMSPTLAGHNGLFSWSSC | ||||||
Disulfide bond | 537↔562 | |||||
Sequence: CKWQFGEKAKLCTLDFKKDICKALWC | ||||||
Disulfide bond | 548↔569 | |||||
Sequence: CTLDFKKDICKALWCHRFGRKC | ||||||
Disulfide bond | 557↔588 | |||||
Sequence: CKALWCHRFGRKCETKFMPAAEGSACGPEMWC | ||||||
Disulfide bond | 582↔593 | |||||
Sequence: CGPEMWCRGGQC | ||||||
Disulfide bond | 617↔654 | |||||
Sequence: CSRSCESGVTHRERVCSSPRPAHGGRFCEGSSRSYKLC | ||||||
Disulfide bond | 621↔659 | |||||
Sequence: CESGVTHRERVCSSPRPAHGGRFCEGSSRSYKLCNTDDC | ||||||
Disulfide bond | 632↔644 | |||||
Sequence: CSSPRPAHGGRFC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 193-273 | Disordered | ||||
Sequence: APSPDHQPHILYKRPAPTNTRRTRRSSEPRPGDPAIPNRWRTSRQAEKNTHTLINPEEMQKTTHKNSTRRRQHYCGRRKKY | ||||||
Compositional bias | 239-253 | Polar residues | ||||
Sequence: EKNTHTLINPEEMQK | ||||||
Domain | 309-514 | Peptidase M12B | ||||
Sequence: LNVETLVVVDRKMMDNHGHENITTYVLTVLNMVSTLFKDGTIGGNINVVIVGLILLDEDQDGLVINHHADHTLNSFCQWQSGLSGREGRRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSVGNIMSPTLAGHNGLFSWSSCSRQYLNRFLSSAQATCLSDEP | ||||||
Domain | 1186-1223 | PLAC | ||||
Sequence: NDVVCKDHFSWCYLVPQHSVCNHKFYGKQCCKSCRQSK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,224
- Mass (Da)137,218
- Last updated2018-06-20 v3
- ChecksumAD6FD08426D499BD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 239-253 | Polar residues | ||||
Sequence: EKNTHTLINPEEMQK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LO018198 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |