E7FFC4 · E7FFC4_DANRE
- ProteinFerroptosis suppressor protein 1
- Geneaifm2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids373 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- H+ + NADH + phylloquinone = NAD+ + phylloquinolThis reaction proceeds in the forward direction.
- H+ + NADH + ubiquinone-10 = NAD+ + ubiquinol-10This reaction proceeds in the forward direction.
- H+ + menadione + NADH = menadiol + NAD+This reaction proceeds in the forward direction.
- H+ + menaquinone-4 + NADH = menaquinol-4 + NAD+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | lipid droplet | |
Cellular Component | mitochondrial membrane | |
Cellular Component | mitochondrion | |
Cellular Component | plasma membrane | |
Molecular Function | electron-transferring-flavoprotein dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | apoptotic mitochondrial changes | |
Biological Process | positive regulation of apoptotic process |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameFerroptosis suppressor protein 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE7FFC4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-298 | FAD/NAD(P)-binding | ||||
Sequence: HVVIVGGGFGGIAAAQHLKHYGVPFMLIDVLDAFHHNVAALRASVQTGFARKTFIPYKETFGLNFLQGRVIRIDTETQTVVLDNGKEVRYSHLILCTGTTGSFPSKHNSVDTYKSAIQKYEDFFHVIKEANAIVVVGGGTTGVEMAAEIKTEFHDKKVVLIHPREEVADPELLPCVKEQAKQVLLEKGVELLLGQKVSNLEELELNVCRSGMVVKTNKNEQVTTDLVICCTGSKINSEAYRSSMSSCLAENGALKVNKHLQVEGFDNVYAVGDCANLSEPKMAYHAG |
Sequence similarities
Belongs to the FAD-dependent oxidoreductase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length373
- Mass (Da)40,471
- Last updated2011-03-08 v1
- Checksum8B68EE8DDB6D7E58
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CABZ01072069 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01072070 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01072071 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |