E7F7X0 · LMOD3_DANRE
- ProteinLeiomodin-3
- Genelmod3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids670 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Essential for the organization of sarcomeric thin filaments in skeletal muscle.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoskeleton | |
Cellular Component | M band | |
Cellular Component | myofibril | |
Cellular Component | striated muscle thin filament | |
Molecular Function | tropomyosin binding | |
Biological Process | actin filament organization | |
Biological Process | muscle contraction | |
Biological Process | myofibril assembly | |
Biological Process | pointed-end actin filament capping | |
Biological Process | skeletal muscle fiber development | |
Biological Process | skeletal muscle thin filament assembly |
Names & Taxonomy
Protein names
- Recommended nameLeiomodin-3
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE7F7X0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Morpholino knockdown of the protein causes short bodies, bent tails, and reduced tail birefringence, consistent with abnormal skeletal muscle organization, in fish larvae, 3 days after fertilization. Larvae exhibit reduced trunk size, that generate less force than that of wild-type counterparts, and aberrant accumulation of alpha-actinin. Mutant embryos show abnormal motor function, with reduced spontaneous coiling and diminished touch-evoked escape responses.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000432424 | 1-670 | Leiomodin-3 | |||
Sequence: MSERTEQESYTDKIDEDEILAGLSAEELKQLQSEMDDIAPDERVPVGLRQKDASHEMTVRDCTEPESEEEIDEDEILAGLSAEELKQLQSEMEEIAPDERVPVGMRQRDQTDKPPTGSFDHRSLVEYLYWEKESKRMLEEERVPTTLLPSQKTNEEHEAKNEDKVEELELVYEEIVEEVEGGQGDAVVDEVIEEVIMEVEEEDKVCDKPVKTDLDATDPTVTSEDGLQRPSESADANVEAKTDQSGLDTETKVNEEKKEDSTEPAPSSYENWVPEKEERVISKLKIPKLALGGNTFVKKTARPSGNETNLESTLDKIRNNNPSVTDVNLNNIENIPKEMLLDYVNSLKKNRHVKTFSIANTGADENVAFTLANMLKENRSITTLNIESNFITGKGIVAIIRCLQFNETLTELRFHNQRHMLGHHAEMEVSRLLKANNTLLKMGYHFELPGPRMVVTNLLTRNLDRQRQQRMEEQKLQQMKEQRKVMEMYEDSLNLPPGMLEMLGGYIPLSLLQNCQNGAEDIPEDSPEPSPQPSPPHQLCKTQHLAPQQHPPNLSTGNLFEEVQLKKTPKRRDPLLEWNQCDERKDGRPNVHLRSVPKKRSIAREGPVDERANLKDMIKTLKPVPRRREPPKVDLTPRDHLLSEIRQSNVAYLKAVPLPKILESQETSLF |
Proteomic databases
Expression
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-64 | Basic and acidic residues | ||||
Sequence: EMDDIAPDERVPVGLRQKDASHEMTVRDCTE | ||||||
Region | 34-72 | Disordered | ||||
Sequence: EMDDIAPDERVPVGLRQKDASHEMTVRDCTEPESEEEID | ||||||
Region | 94-120 | Disordered | ||||
Sequence: EIAPDERVPVGMRQRDQTDKPPTGSFD | ||||||
Region | 139-165 | Disordered | ||||
Sequence: EEERVPTTLLPSQKTNEEHEAKNEDKV | ||||||
Coiled coil | 150-183 | |||||
Sequence: SQKTNEEHEAKNEDKVEELELVYEEIVEEVEGGQ | ||||||
Region | 202-274 | Disordered | ||||
Sequence: EDKVCDKPVKTDLDATDPTVTSEDGLQRPSESADANVEAKTDQSGLDTETKVNEEKKEDSTEPAPSSYENWVP | ||||||
Compositional bias | 216-244 | Polar residues | ||||
Sequence: ATDPTVTSEDGLQRPSESADANVEAKTDQ | ||||||
Compositional bias | 245-264 | Basic and acidic residues | ||||
Sequence: SGLDTETKVNEEKKEDSTEP | ||||||
Coiled coil | 464-494 | |||||
Sequence: DRQRQQRMEEQKLQQMKEQRKVMEMYEDSLN | ||||||
Region | 517-556 | Disordered | ||||
Sequence: NGAEDIPEDSPEPSPQPSPPHQLCKTQHLAPQQHPPNLST | ||||||
Compositional bias | 537-556 | Polar residues | ||||
Sequence: HQLCKTQHLAPQQHPPNLST | ||||||
Domain | 637-656 | WH2 | ||||
Sequence: PRDHLLSEIRQSNVAYLKAV |
Sequence similarities
Belongs to the tropomodulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length670
- Mass (Da)76,458
- Last updated2011-03-08 v1
- ChecksumE15DCAB4FBB0E37F
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9QA08 | A0A8M9QA08_DANRE | lmod3 | 670 | ||
A0A2R8QDE5 | A0A2R8QDE5_DANRE | lmod3 | 670 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-64 | Basic and acidic residues | ||||
Sequence: EMDDIAPDERVPVGLRQKDASHEMTVRDCTE | ||||||
Compositional bias | 216-244 | Polar residues | ||||
Sequence: ATDPTVTSEDGLQRPSESADANVEAKTDQ | ||||||
Compositional bias | 245-264 | Basic and acidic residues | ||||
Sequence: SGLDTETKVNEEKKEDSTEP | ||||||
Compositional bias | 537-556 | Polar residues | ||||
Sequence: HQLCKTQHLAPQQHPPNLST |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX897727 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |