E7F6Z8 · E7F6Z8_DANRE

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site227Proton donor
Binding site227-231AMP (UniProtKB | ChEBI)
Binding site231Zn2+ 1 (UniProtKB | ChEBI)
Binding site267Zn2+ 1 (UniProtKB | ChEBI)
Binding site268AMP (UniProtKB | ChEBI)
Binding site268Zn2+ 1 (UniProtKB | ChEBI)
Binding site268Zn2+ 2 (UniProtKB | ChEBI)
Binding site374AMP (UniProtKB | ChEBI)
Binding site374Zn2+ 1 (UniProtKB | ChEBI)
Binding site425AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentneuronal cell body
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological ProcesscAMP-mediated signaling
Biological Processpronephros development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      pde1a

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    E7F6Z8
  • Secondary accessions
    • A0A8M2BFE4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain150-528PDEase
Region472-492Disordered
Region532-611Disordered
Compositional bias543-558Polar residues
Compositional bias565-591Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    69,670
  • Last updated
    2018-06-20 v3
  • Checksum
    D2B3802B787FA1A9
MDSLANDTDGLENSLKYSKCDQTEKMWIRLKGMQKYKNTSQRLRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPSVITALKDVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKIISPLIEEAVKSGGVRRSSLTGRGSAAVVESVQRHSDRGSNDECGGSTDYSLCGIDQKHVRHLLSEIIQNNKERWKELSVQELANKQHERMSDLQEEPMRSTQLTLSQENHDSESKSLNELNNTDSTHSSQDSLDQSSQSPTEGAGDASPEEHSSETLPWNGKSA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8RXK7A0A2R8RXK7_DANREpde1a587

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias543-558Polar residues
Compositional bias565-591Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX548025
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CABZ01078846
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CABZ01078847
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CU929363
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
FO744868
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp