E7F6Z8 · E7F6Z8_DANRE
- ProteinPhosphodiesterase
- Genepde1a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids611 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 227 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 227-231 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNLIH | ||||||
Binding site | 231 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 267 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 268 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 268 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 268 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 374 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 374 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 425 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | neuronal cell body | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | cAMP-mediated signaling | |
Biological Process | pronephros development |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE7F6Z8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 150-528 | PDEase | ||||
Sequence: AGLTYPPSVITALKDVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKIISPLIEEAVKSGGVRRSSLTGRGSAAVVESVQRHSDRGSNDECGGSTDYSLCGIDQKHVRHLLSEIIQNNKERWKELSVQE | ||||||
Region | 472-492 | Disordered | ||||
Sequence: AAVVESVQRHSDRGSNDECGG | ||||||
Region | 532-611 | Disordered | ||||
Sequence: KQHERMSDLQEEPMRSTQLTLSQENHDSESKSLNELNNTDSTHSSQDSLDQSSQSPTEGAGDASPEEHSSETLPWNGKSA | ||||||
Compositional bias | 543-558 | Polar residues | ||||
Sequence: EPMRSTQLTLSQENHD | ||||||
Compositional bias | 565-591 | Polar residues | ||||
Sequence: NELNNTDSTHSSQDSLDQSSQSPTEGA |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)69,670
- Last updated2018-06-20 v3
- ChecksumD2B3802B787FA1A9
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8RXK7 | A0A2R8RXK7_DANRE | pde1a | 587 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 543-558 | Polar residues | ||||
Sequence: EPMRSTQLTLSQENHD | ||||||
Compositional bias | 565-591 | Polar residues | ||||
Sequence: NELNNTDSTHSSQDSLDQSSQSPTEGA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX548025 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01078846 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01078847 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CU929363 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FO744868 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |