E7F6Z2 · E7F6Z2_DANRE
- ProteinSynaptic vesicle glycoprotein 2A
- Genesv2a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids733 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | neuron projection | |
Cellular Component | synaptic vesicle membrane | |
Molecular Function | transmembrane transporter activity | |
Biological Process | chemical synaptic transmission | |
Biological Process | neuronal action potential propagation | |
Biological Process | neurotransmitter transport | |
Biological Process | swimming behavior |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSynaptic vesicle glycoprotein 2A
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE7F6Z2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 158-185 | Helical | ||||
Sequence: WTLYFVLGLALMADGVEIFVVGFVLPSA | ||||||
Transmembrane | 197-215 | Helical | ||||
Sequence: GMLGLIVYLGMMVGAFVWG | ||||||
Transmembrane | 227-248 | Helical | ||||
Sequence: LLISLSINSVFAFFSSFVQGYS | ||||||
Transmembrane | 254-273 | Helical | ||||
Sequence: RLLSGVGIGGSIPIVFSYYS | ||||||
Transmembrane | 285-307 | Helical | ||||
Sequence: LSWLCMFWMIGGIYAAAMAWAII | ||||||
Transmembrane | 327-346 | Helical | ||||
Sequence: VFVLVCAFPSVAAIAALTTM | ||||||
Transmembrane | 438-460 | Helical | ||||
Sequence: ITYMMMAVWFSMSFSYYGLTVWF | ||||||
Transmembrane | 586-609 | Helical | ||||
Sequence: YMIYFVSFLGTLAVLPGNIVSALL | ||||||
Transmembrane | 616-635 | Helical | ||||
Sequence: LRMLAGSSVISCVSCFFLSF | ||||||
Transmembrane | 641-663 | Helical | ||||
Sequence: AMIALLCLFGGISIASWNALDVL | ||||||
Transmembrane | 675-698 | Helical | ||||
Sequence: TAFGFLNALCKLAAVLGISIFQSF | ||||||
Transmembrane | 704-722 | Helical | ||||
Sequence: AVPILFASGALAAGSFLAL |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-92 | Disordered | ||||
Sequence: KEVKRHAGKKVGRHVDKMTDEYTKRSYTRFEEDDDDDDYPVQAQDGSYYRSNSRANDDEGAHSDSTEGHDEDD | ||||||
Compositional bias | 32-50 | Basic and acidic residues | ||||
Sequence: RHVDKMTDEYTKRSYTRFE | ||||||
Compositional bias | 74-88 | Basic and acidic residues | ||||
Sequence: ANDDEGAHSDSTEGH | ||||||
Domain | 160-728 | Major facilitator superfamily (MFS) profile | ||||
Sequence: LYFVLGLALMADGVEIFVVGFVLPSAEKDMCLSEPNKGMLGLIVYLGMMVGAFVWGGLADRIGRRQTLLISLSINSVFAFFSSFVQGYSSFLFCRLLSGVGIGGSIPIVFSYYSEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVAAIAALTTMPESPRFYLENGKHDEAWMILKQVHDTNMRAKGYPERVFSVTTIKTVKQMDELVDMGGEATAWHQRWRIKLTNLFHQVWGNFLTVFNPEYRRITYMMMAVWFSMSFSYYGLTVWFPDMIKYLQKQEYSSRTKVFIKEKVEHVTFNFTLENQIHRNGEYFNNKFLNLKMKSMVFEDSLFEECYFEDITSSNTFFRNCTFISTLFYNTDLFKYRLINSKLINSTFLHNKEGCMLDFSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVISCVSCFFLSFGNSESAMIALLCLFGGISIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFQSFVGITKAVPILFASGALAAGSFLALKLPETR |
Sequence similarities
Belongs to the major facilitator superfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length733
- Mass (Da)83,488
- Last updated2015-12-09 v2
- ChecksumFB82DB4568624174
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 32-50 | Basic and acidic residues | ||||
Sequence: RHVDKMTDEYTKRSYTRFE | ||||||
Compositional bias | 74-88 | Basic and acidic residues | ||||
Sequence: ANDDEGAHSDSTEGH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX537142 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |