E7EX57 · E7EX57_HUMAN
- ProteinMultidrug and toxin extrusion protein 1
- GeneSLC47A1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- H+(in) + thiamine(out) = H+(out) + thiamine(in)
- agmatine(in) + H+(out) = agmatine(out) + H+(in)This reaction proceeds in the forward and the backward directions.
- creatinine(in) + H+(out) = creatinine(out) + H+(in)
- estrone 3-sulfate(in) + H+(out) = estrone 3-sulfate(out) + H+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Names & Taxonomy
Protein names
- Recommended nameMultidrug and toxin extrusion protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE7EX57
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 37-62 | Helical | ||||
Sequence: ALLVLAGPAFLVQLMVFLISFISSVF | ||||||
Transmembrane | 97-121 | Helical | ||||
Sequence: ALVLLLCCFPCWALFLNTQHILLLF | ||||||
Transmembrane | 133-150 | Helical | ||||
Sequence: TYVTIFIPALPATFLYML | ||||||
Transmembrane | 162-182 | Helical | ||||
Sequence: LPQIVTGVAANLVNALANYLF | ||||||
Transmembrane | 194-213 | Helical | ||||
Sequence: ALANLISQYTLALLLFLYIL | ||||||
Transmembrane | 233-253 | Helical | ||||
Sequence: WASFLRLAIPSMLMLCMEWWA | ||||||
Transmembrane | 274-295 | Helical | ||||
Sequence: IVYELAIIVYMVPAGFSVAASV | ||||||
Transmembrane | 315-334 | Helical | ||||
Sequence: VSLLITVLFAVAFSVLLLSC | ||||||
Transmembrane | 355-376 | Helical | ||||
Sequence: VVPIYAVSHLFEALACTSGGVL | ||||||
Transmembrane | 391-413 | Helical | ||||
Sequence: IGYYVVGLPIGIALMFATTLGVM |
Keywords
- Cellular component
Disease & Variants
Variants
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The viewer provides 558 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 23 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)48,027
- Last updated2011-03-08 v1
- Checksum5255E025EFD592F2
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC004448 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC025627 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |