E7EWX6 · E7EWX6_HUMAN
- ProteinNAD-dependent protein deacetylase sirtuin-2
- GeneSIRT2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids237 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- H2O + N6-hexadecanoyl-L-lysyl-[protein] + NAD+ = 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamideThis reaction proceeds in the forward direction.
- H2O + N6-tetradecanoyl-L-lysyl-[protein] + NAD+ = 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamideThis reaction proceeds in the forward direction.
Cofactor
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | cytosol | |
Cellular Component | microtubule | |
Cellular Component | midbody | |
Cellular Component | myelin sheath | |
Cellular Component | nucleolus | |
Cellular Component | plasma membrane | |
Cellular Component | spindle | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ binding | |
Molecular Function | transferase activity |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase sirtuin-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE7EWX6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 16 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-237 | Deacetylase sirtuin-type | ||||
Sequence: RLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length237
- Mass (Da)27,143
- Last updated2011-03-08 v1
- Checksum866C96230F5C0649
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8IXJ6 | SIR2_HUMAN | SIRT2 | 389 | ||
C9J3U7 | C9J3U7_HUMAN | SIRT2 | 78 | ||
F8WF57 | F8WF57_HUMAN | SIRT2 | 39 | ||
F8WCF4 | F8WCF4_HUMAN | SIRT2 | 111 | ||
F8WDM4 | F8WDM4_HUMAN | SIRT2 | 52 | ||
F8WBT6 | F8WBT6_HUMAN | SIRT2 | 96 | ||
C9JZQ0 | C9JZQ0_HUMAN | SIRT2 | 130 | ||
C9JR33 | C9JR33_HUMAN | SIRT2 | 73 | ||
B5MCS1 | B5MCS1_HUMAN | SIRT2 | 169 | ||
A0A0A0MRF5 | A0A0A0MRF5_HUMAN | SIRT2 | 234 | ||
A0AAG2T947 | A0AAG2T947_HUMAN | SIRT2 | 389 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 237 | |||||
Sequence: S |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC011455 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |