E7EQZ4 · E7EQZ4_HUMAN
- ProteinSurvival motor neuron protein
- GeneSMN1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids294 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Cajal body | |
Cellular Component | cytosol | |
Cellular Component | Gemini of coiled bodies | |
Cellular Component | neuron projection | |
Cellular Component | nuclear body | |
Cellular Component | perikaryon | |
Cellular Component | Z disc | |
Molecular Function | RNA binding | |
Biological Process | mRNA processing | |
Biological Process | nervous system development | |
Biological Process | RNA splicing |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSurvival motor neuron protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE7EQZ4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 217 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 4 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 5 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 8 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 18 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 25 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 28 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 31 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 37 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 63 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 68 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 69 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 85 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 88 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-32 | Disordered | ||||
Sequence: MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSD | ||||||
Region | 59-88 | Disordered | ||||
Sequence: ICETSGKPKTTPKRKPAKKNKSQKKNTAAS | ||||||
Domain | 91-151 | Tudor | ||||
Sequence: QWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANN | ||||||
Compositional bias | 156-187 | Polar residues | ||||
Sequence: AQENENESQVSTDESENSRSPGNKSDNIKPKS | ||||||
Region | 156-222 | Disordered | ||||
Sequence: AQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPP | ||||||
Compositional bias | 190-222 | Pro residues | ||||
Sequence: WNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPP |
Sequence similarities
Belongs to the SMN family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length294
- Mass (Da)31,690
- Last updated2011-03-08 v1
- ChecksumED66C6D7AEF802BB
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q16637 | SMN_HUMAN | SMN2 | 294 | ||
H0YBZ9 | H0YBZ9_HUMAN | SMN2 | 79 | ||
B4DP61 | B4DP61_HUMAN | SMN1 | 227 | ||
A0A0G2JQN8 | A0A0G2JQN8_HUMAN | SMN1 | 149 | ||
A0A0G2JRX5 | A0A0G2JRX5_HUMAN | SMN1 | 143 | ||
A0A0G2JRY6 | A0A0G2JRY6_HUMAN | SMN1 | 180 | ||
U3KPX7 | U3KPX7_HUMAN | SMN2 | 46 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 156-187 | Polar residues | ||||
Sequence: AQENENESQVSTDESENSRSPGNKSDNIKPKS | ||||||
Compositional bias | 190-222 | Pro residues | ||||
Sequence: WNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC044797 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC139834 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC140134 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |