E7EQZ4 · E7EQZ4_HUMAN

  • Protein
    Survival motor neuron protein
  • Gene
    SMN1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCajal body
Cellular Componentcytosol
Cellular ComponentGemini of coiled bodies
Cellular Componentneuron projection
Cellular Componentnuclear body
Cellular Componentperikaryon
Cellular ComponentZ disc
Molecular FunctionRNA binding
Biological ProcessmRNA processing
Biological Processnervous system development
Biological ProcessRNA splicing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Survival motor neuron protein

Gene names

    • Name
      SMN1
    • Synonyms
      SMN2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E7EQZ4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 217 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)4PRIDEPhosphoserine
Modified residue (large scale data)5PRIDEPhosphoserine
Modified residue (large scale data)8PRIDEPhosphoserine
Modified residue (large scale data)18PRIDEPhosphoserine
Modified residue (large scale data)25PRIDEPhosphothreonine
Modified residue (large scale data)28PRIDEPhosphoserine
Modified residue (large scale data)31PRIDEPhosphoserine
Modified residue (large scale data)37PRIDEPhosphothreonine
Modified residue (large scale data)63PRIDEPhosphoserine
Modified residue (large scale data)68PRIDEPhosphothreonine
Modified residue (large scale data)69PRIDEPhosphothreonine
Modified residue (large scale data)85PRIDEPhosphothreonine
Modified residue (large scale data)88PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-32Disordered
Region59-88Disordered
Domain91-151Tudor
Compositional bias156-187Polar residues
Region156-222Disordered
Compositional bias190-222Pro residues

Sequence similarities

Belongs to the SMN family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    31,690
  • Last updated
    2011-03-08 v1
  • Checksum
    ED66C6D7AEF802BB
MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMTGFHCVSQDGLNLLTP

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q16637SMN_HUMANSMN2294
H0YBZ9H0YBZ9_HUMANSMN279
B4DP61B4DP61_HUMANSMN1227
A0A0G2JQN8A0A0G2JQN8_HUMANSMN1149
A0A0G2JRX5A0A0G2JRX5_HUMANSMN1143
A0A0G2JRY6A0A0G2JRY6_HUMANSMN1180
U3KPX7U3KPX7_HUMANSMN246

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias156-187Polar residues
Compositional bias190-222Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC044797
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC139834
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC140134
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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