E7CWU1 · E7CWU1_SIV
- ProteinEnvelope glycoprotein gp160
- Geneenv
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids879 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell endosome membrane | |
Cellular Component | host cell plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | viral envelope | |
Cellular Component | virion membrane | |
Molecular Function | structural molecule activity | |
Biological Process | apoptotic process | |
Biological Process | membrane fusion involved in viral entry into host cell | |
Biological Process | symbiont entry into host cell | |
Biological Process | virion attachment to host cell |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEnvelope glycoprotein gp160
- Cleaved into 2 chains
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus
- Virus hosts
Accessions
- Primary accessionE7CWU1
Subcellular Location
UniProt Annotation
GO Annotation
Host cell membrane ; Peripheral membrane protein
Host cell membrane ; Single-pass type I membrane protein
Host endosome membrane ; Peripheral membrane protein
Host endosome membrane ; Single-pass type I membrane protein
Virion membrane ; Peripheral membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-32 | Helical | |||
Transmembrane | 527-548 | Helical | |||
Transmembrane | 690-711 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 24-525 | Human immunodeficiency virus 1 envelope glycoprotein Gp120 | |||
Domain | 543-738 | Retroviral envelope protein GP41-like | |||
Coiled coil | 637-664 | ||||
Domain
The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length879
- Mass (Da)100,875
- Last updated2011-03-08 v1
- Checksum2ED923B3D28A7413
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM800206 EMBL· GenBank· DDBJ | ADV17146.1 EMBL· GenBank· DDBJ | Genomic RNA |