E7CWH3 · E7CWH3_TRIIA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number

Gene names

    • Name
      ND2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • UAM10101
    • UAM10176
    • UAM10496
    • UAM13434
    • UAM15181
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Scolopacidae > Tringa

Accessions

  • Primary accession
    E7CWH3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane55-75Helical
Transmembrane95-114Helical
Transmembrane151-170Helical
Transmembrane177-195Helical
Transmembrane201-218Helical
Transmembrane239-260Helical
Transmembrane280-301Helical
Transmembrane322-342Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-287NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain289-342NADH dehydrogenase subunit 2 C-terminal

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    344
  • Mass (Da)
    38,153
  • Last updated
    2011-03-08 v1
  • MD5 Checksum
    841C00CFCA5C0B966D15B34D18418A24
DPHAKLIFYMSLFMGTTITISSNHWMMAWTGLEINTLAIIPLISKSHHPRAIEAAIKYFLVQAAASALVLFSSMINAWFTGQWDITQLTHSTSCLLLTTAIAMKLGLVPFHFWFPEVLQGSTLSTALLLSTMMKFPPITILFLTSNSLNPTLLTTMAIASAGLGGWMGLNQTQIRKILAFSSIAHLGWMTIIIVYNPKLTLLTFYLYSLMTATVFLSLNTIKVLKLSTMMTSWTKTPMLNATLMLTLLSLAGLPPLTGFLPKWLIIQELTKQEMTPAATIIAMLSLLGLFFYLRLAYYSTITLPPNSTNHMKQWHMNKSTNTLLAILTSLSISLLPLSPMILAT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue344

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM640876
EMBL· GenBank· DDBJ
ADU86192.1
EMBL· GenBank· DDBJ
Genomic DNA
HM640877
EMBL· GenBank· DDBJ
ADU86193.1
EMBL· GenBank· DDBJ
Genomic DNA
HM640878
EMBL· GenBank· DDBJ
ADU86194.1
EMBL· GenBank· DDBJ
Genomic DNA
HM640879
EMBL· GenBank· DDBJ
ADU86195.1
EMBL· GenBank· DDBJ
Genomic DNA
HM640880
EMBL· GenBank· DDBJ
ADU86196.1
EMBL· GenBank· DDBJ
Genomic DNA
HM640881
EMBL· GenBank· DDBJ
ADU86197.1
EMBL· GenBank· DDBJ
Genomic DNA
HM640882
EMBL· GenBank· DDBJ
ADU86198.1
EMBL· GenBank· DDBJ
Genomic DNA
HM776976
EMBL· GenBank· DDBJ
ADV04212.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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