E7BQV0 · NPR1_MALHU

Function

function

Salicylic acid (SA)-binding substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Transcription cofactor that represses gene expression in the absence of salicylic acid (SA), when attached to negative cis-elements (W-box) with WRKY transcription factors, but stimulates gene expression upon activation by SA, when sumoylated and attached to positive cis-elements (as-1) with TGA transcription factors, thus confering immunity through a series of gene regulations ending in a significant increase in antimicrobial and defense genes expression (By similarity).
Probable component of the salicylic acid (SA) defense signaling pathway and pathogen-induced systemic acquired resistance (SAR) (Probable). May be involved in disease resistance against fungal pathogens (Probable). May be involved in tolerance to salt and osmotic stresses (PubMed:24407603).

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for binding site.

158650100150200250300350400450500550
TypeIDPosition(s)Description
Binding site145Zn2+ (UniProtKB | ChEBI)
Binding site150Zn2+ (UniProtKB | ChEBI)
Binding site152Zn2+ (UniProtKB | ChEBI)
Binding site155Zn2+ (UniProtKB | ChEBI)
Binding site433salicylate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear body
Molecular Functionmetal ion binding
Biological Processdefense response
Biological Processregulation of jasmonic acid mediated signaling pathway
Biological Processregulation of salicylic acid mediated signaling pathway
Biological Processresponse to salt stress
Biological Processresponse to water deprivation
Biological Processsystemic acquired resistance, salicylic acid mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BTB/POZ domain and ankyrin repeat-containing protein NPR1
  • Short names
    MhNPR1
  • Alternative names
    • NPR1 homolog

Gene names

    • Name
      NPR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Rosaceae > Amygdaloideae > Maleae > Malus

Accessions

  • Primary accession
    E7BQV0
  • Secondary accessions
    • G8XUV9

Subcellular Location

Cytoplasm
Nucleus
Nucleus, nuclear body
Note: Accumulation in nucleus after induction by salicylic acid (SA) treatment or after pathogen infection.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004474791-586BTB/POZ domain and ankyrin repeat-containing protein NPR1

Expression

Tissue specificity

Highly expressed in leaves (PubMed:21973266).
Expressed at low levels in roots and stems (PubMed:21973266).

Induction

Induced by salicylic acid (SA) in roots, stems and leaves (PubMed:21973266).
Induced by jasmonate in roots (PubMed:21973266).
Induced by ethylene in roots and leaves (PubMed:21973266).
Induced by salt stress, osmotic shock, cold stress and abscisic acid (ABA) (PubMed:24407603).

Structure

Family & Domains

Features

Showing features for domain, zinc finger, repeat, region, compositional bias.

TypeIDPosition(s)Description
Domain63-139BTB
Zinc finger140-156C2HC-type
Repeat266-296ANK 1
Repeat298-325ANK 2
Repeat329-358ANK 3
Region388-522Salicylic acid-binding core (SBC)
Compositional bias561-578Polar residues
Region561-586Disordered

Domain

The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    586
  • Mass (Da)
    65,083
  • Last updated
    2019-07-03 v2
  • Checksum
    11C480E7AA714DD3
MAHSAEPSSSLSFTSSPHLSNGSISHNLSCSGSESVPSLEVISLSKLSSSLEQLLIDPGCDYSDADIVVEGIPVGVHRCILASRSGFFRELFKREKGSSGKEDRPKYCMSDFLPYGDVGYEAFLVFLSYVYTGKLKPSPVEVSTCVHNVCAHDACRPAINFVVELMYAASIFQMPDLVSIFERRLLNFVGKALSDNVVPILLVAFHCQLNQLIDQCVDRVARSDIDDISLEKGLPDEVVKKIKILRRNYQQDSDPNLPPADPLHEKRIRRIHKALDSDDVELVKLLLTESNITLDEANALHYAAAYCDPKVVTEVLALGLADVNLRNSRGYTALHIAVMRKEPSIIVLLLTKGARASELTSDGQSAVSICRRLTRPKDYHSKTEQGQEANKDRICIDVLEREMRRNPMAGDASISSQIMPDDLHMELLNLENRVALARLFFPAEAKLAMVIAHAETSEFAAPSSSKGSSGNLMEVDLNETPTVQNKRLHSRLEALMKTVRLGRCYFPHCSEVLDKFIDDDLPHLFYLEPGSSDEQKVKRRRFMELKEEVQKAFDKDKAECNLSGLSSSSSTTSPEKIGANQKVREP

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict93in Ref. 1; ACU78081
Sequence conflict163-166in Ref. 1; ADP95762
Sequence conflict226in Ref. 1; ACU78081
Sequence conflict258in Ref. 1; ACU78081
Sequence conflict285in Ref. 1; ACU78081
Sequence conflict333in Ref. 1; ACU78081
Sequence conflict383in Ref. 1; ACU78081
Sequence conflict485in Ref. 1; ACU78081
Compositional bias561-578Polar residues
Sequence conflict566in Ref. 1; ACU78081
Sequence conflict575in Ref. 1; ACU78081

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ598141
EMBL· GenBank· DDBJ
ACU78081.1
EMBL· GenBank· DDBJ
mRNA
GU183100
EMBL· GenBank· DDBJ
ADP95762.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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