E6ZGB4 · PHF2_DICLA

Function

function

Lysine demethylase that demethylates both histones and non-histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).

Caution

In contrast to the related histone demethylases jhdm1d and phf8, the conserved active His in position 321 is replaced by an Asn. However, the presence of an Asn residue neither affects binding to the catalytic iron nor abolishes demethylase activity.

Features

Showing features for binding site.

110811002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site2462-oxoglutarate (UniProtKB | ChEBI)
Binding site249Fe cation (UniProtKB | ChEBI); catalytic
Binding site251Fe cation (UniProtKB | ChEBI); catalytic
Binding site2592-oxoglutarate (UniProtKB | ChEBI)
Binding site2662-oxoglutarate (UniProtKB | ChEBI)
Binding site321Fe cation (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentkinetochore
Cellular Componentnucleolus
Molecular Functiondioxygenase activity
Molecular Functionhistone H3K9 demethylase activity
Molecular Functioniron ion binding
Molecular Functionmethylated histone binding
Molecular Functiontranscription coactivator activity
Biological Processprotein demethylation
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysine-specific demethylase phf2
  • EC number
  • Alternative names
    • PHD finger protein 2

Gene names

    • Name
      phf2
    • ORF names
      DLA_It00560

Organism names

Accessions

  • Primary accession
    E6ZGB4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004109021-1081Lysine-specific demethylase phf2
Modified residue1022Phosphoserine; by PKA

Keywords

Structure

Family & Domains

Features

Showing features for zinc finger, domain, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger5-56PHD-type
Domain197-353JmjC
Region450-560Disordered
Compositional bias496-510Pro residues
Compositional bias512-531Basic and acidic residues
Region722-756Disordered
Compositional bias725-747Basic and acidic residues
Compositional bias770-840Polar residues
Region770-1062Disordered
Compositional bias851-874Basic and acidic residues
Compositional bias888-905Basic and acidic residues
Compositional bias972-1004Polar residues
Compositional bias1018-1043Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,081
  • Mass (Da)
    120,753
  • Last updated
    2011-03-08 v1
  • Checksum
    F02DE03919A9484C
MATVPVYCICRLPYDVTQFMIECDACKDWFHGSCVGVDEDDAPDIDIYHCPNCEKTHGKSTLKKKKNWSKHDTGQSTDIKAVQNGSQVFIKELRSRTFPSADDVVVKLSGSQLTMDYLEENGFNEPILAQKKDGLGLSMPAPTFYISDVENYVGPDVGVDVVDVTKQTDSKMKLKEFVDYYYSTNRKKVLNVINLEFSDTRMNSIVESPQIVRRLSWVENYWPDDALLGKPKVTKYCLICVKDSYTDFHIECGGASVWYHVLKGEKIFFLIKPTSANLSLYERWRSSSNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWINAILTPVDCLAFSGHFVHNLSVEMQMRAYEIEKRLKVKTLTPFPNFETACWYVGRHLLERFKGLHKANKQPAPYLIHGAKIINGAFRAWTKKQALLEHEDELPENMKPSQLIKDLAKEIRLSENATKAIKSEPSIKVPVEEPPSTHSEPEEPVSPAHVPSPSREKARKKASKPPKPPKPPKPPKMPKAPKPPKVPKVKEGGKKKAKKVKESSPPPKPSSFAALESHAKDILSKMDQPKKTKAVKNVLSMSEKEISKQNNLEKFEIREQNKNKTEAKWKYKNSKPDSLLKMEEECKFDRTLLSGNKDKFSFTMSHKKMLGSKTLKPQTNSSVFGSLQNLKEDKTKPVRDEYEYVSDEGELKIDEFPIRRKKNTVKRDQSFLSDIREPIQPAKKPKFQPLVTKNVDSSDEETLHIDTEAKPEVKSRNSKVKKKGGSAAGILDLLQASKQVGGIDYSTNSQPPASPSTQEAIQGMLSMANLSSSDSLQQPWSNSQSKNNSQSKSNSHGAQGGKKGSGGGGNNSKRPTKRLPKKPRKSSSIESLDYDDDQDHMDACFKDSDYVYPSLESEEDNPVFKSRSKKRKSSDDTPYSPTARVGPSVPRQERPARDGARVASIETGLAAAAAKLSHQEEQQKTKKKKKSTKKKAIVIEEPPKISQDSSSPEHNLDSQDGSLTDHEFNTGTVKSPGGPQPMAPGVFLSQRRPSMSSPNNSTNSTSTNSSSMAKGDRVGSADAKAKRLKKGMATAKQRLGKILKIHRNGKLLL

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8P4G513A0A8P4G513_DICLA1042
A0A8P4K2T3A0A8P4K2T3_DICLA926
A0A8P4KFF3A0A8P4KFF3_DICLA449
A0A8C4ITH2A0A8C4ITH2_DICLA880
A0A8C4IR91A0A8C4IR91_DICLA470

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias496-510Pro residues
Compositional bias512-531Basic and acidic residues
Compositional bias725-747Basic and acidic residues
Compositional bias770-840Polar residues
Compositional bias851-874Basic and acidic residues
Compositional bias888-905Basic and acidic residues
Compositional bias972-1004Polar residues
Compositional bias1018-1043Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FQ310506
EMBL· GenBank· DDBJ
CBN80631.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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