E6ZGB4 · PHF2_DICLA
- ProteinLysine-specific demethylase phf2
- Genephf2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1081 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Lysine demethylase that demethylates both histones and non-histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 246 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 249 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 251 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 259 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 266 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 321 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: N |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | kinetochore | |
Cellular Component | nucleolus | |
Molecular Function | dioxygenase activity | |
Molecular Function | histone H3K9 demethylase activity | |
Molecular Function | iron ion binding | |
Molecular Function | methylated histone binding | |
Molecular Function | transcription coactivator activity | |
Biological Process | protein demethylation | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysine-specific demethylase phf2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Moronidae > Dicentrarchus
Accessions
- Primary accessionE6ZGB4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000410902 | 1-1081 | Lysine-specific demethylase phf2 | |||
Sequence: MATVPVYCICRLPYDVTQFMIECDACKDWFHGSCVGVDEDDAPDIDIYHCPNCEKTHGKSTLKKKKNWSKHDTGQSTDIKAVQNGSQVFIKELRSRTFPSADDVVVKLSGSQLTMDYLEENGFNEPILAQKKDGLGLSMPAPTFYISDVENYVGPDVGVDVVDVTKQTDSKMKLKEFVDYYYSTNRKKVLNVINLEFSDTRMNSIVESPQIVRRLSWVENYWPDDALLGKPKVTKYCLICVKDSYTDFHIECGGASVWYHVLKGEKIFFLIKPTSANLSLYERWRSSSNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWINAILTPVDCLAFSGHFVHNLSVEMQMRAYEIEKRLKVKTLTPFPNFETACWYVGRHLLERFKGLHKANKQPAPYLIHGAKIINGAFRAWTKKQALLEHEDELPENMKPSQLIKDLAKEIRLSENATKAIKSEPSIKVPVEEPPSTHSEPEEPVSPAHVPSPSREKARKKASKPPKPPKPPKPPKMPKAPKPPKVPKVKEGGKKKAKKVKESSPPPKPSSFAALESHAKDILSKMDQPKKTKAVKNVLSMSEKEISKQNNLEKFEIREQNKNKTEAKWKYKNSKPDSLLKMEEECKFDRTLLSGNKDKFSFTMSHKKMLGSKTLKPQTNSSVFGSLQNLKEDKTKPVRDEYEYVSDEGELKIDEFPIRRKKNTVKRDQSFLSDIREPIQPAKKPKFQPLVTKNVDSSDEETLHIDTEAKPEVKSRNSKVKKKGGSAAGILDLLQASKQVGGIDYSTNSQPPASPSTQEAIQGMLSMANLSSSDSLQQPWSNSQSKNNSQSKSNSHGAQGGKKGSGGGGNNSKRPTKRLPKKPRKSSSIESLDYDDDQDHMDACFKDSDYVYPSLESEEDNPVFKSRSKKRKSSDDTPYSPTARVGPSVPRQERPARDGARVASIETGLAAAAAKLSHQEEQQKTKKKKKSTKKKAIVIEEPPKISQDSSSPEHNLDSQDGSLTDHEFNTGTVKSPGGPQPMAPGVFLSQRRPSMSSPNNSTNSTSTNSSSMAKGDRVGSADAKAKRLKKGMATAKQRLGKILKIHRNGKLLL | ||||||
Modified residue | 1022 | Phosphoserine; by PKA | ||||
Sequence: S |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for zinc finger, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 5-56 | PHD-type | ||||
Sequence: PVYCICRLPYDVTQFMIECDACKDWFHGSCVGVDEDDAPDIDIYHCPNCEKT | ||||||
Domain | 197-353 | JmjC | ||||
Sequence: FSDTRMNSIVESPQIVRRLSWVENYWPDDALLGKPKVTKYCLICVKDSYTDFHIECGGASVWYHVLKGEKIFFLIKPTSANLSLYERWRSSSNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWINAILTPVDCLAFSGHFVHNLSVEMQMRAYEIEK | ||||||
Region | 450-560 | Disordered | ||||
Sequence: KSEPSIKVPVEEPPSTHSEPEEPVSPAHVPSPSREKARKKASKPPKPPKPPKPPKMPKAPKPPKVPKVKEGGKKKAKKVKESSPPPKPSSFAALESHAKDILSKMDQPKKT | ||||||
Compositional bias | 496-510 | Pro residues | ||||
Sequence: PPKPPKPPKMPKAPK | ||||||
Compositional bias | 512-531 | Basic and acidic residues | ||||
Sequence: PKVPKVKEGGKKKAKKVKES | ||||||
Region | 722-756 | Disordered | ||||
Sequence: NVDSSDEETLHIDTEAKPEVKSRNSKVKKKGGSAA | ||||||
Compositional bias | 725-747 | Basic and acidic residues | ||||
Sequence: SSDEETLHIDTEAKPEVKSRNSK | ||||||
Compositional bias | 770-840 | Polar residues | ||||
Sequence: GIDYSTNSQPPASPSTQEAIQGMLSMANLSSSDSLQQPWSNSQSKNNSQSKSNSHGAQGGKKGSGGGGNNS | ||||||
Region | 770-1062 | Disordered | ||||
Sequence: GIDYSTNSQPPASPSTQEAIQGMLSMANLSSSDSLQQPWSNSQSKNNSQSKSNSHGAQGGKKGSGGGGNNSKRPTKRLPKKPRKSSSIESLDYDDDQDHMDACFKDSDYVYPSLESEEDNPVFKSRSKKRKSSDDTPYSPTARVGPSVPRQERPARDGARVASIETGLAAAAAKLSHQEEQQKTKKKKKSTKKKAIVIEEPPKISQDSSSPEHNLDSQDGSLTDHEFNTGTVKSPGGPQPMAPGVFLSQRRPSMSSPNNSTNSTSTNSSSMAKGDRVGSADAKAKRLKKGMAT | ||||||
Compositional bias | 851-874 | Basic and acidic residues | ||||
Sequence: PRKSSSIESLDYDDDQDHMDACFK | ||||||
Compositional bias | 888-905 | Basic and acidic residues | ||||
Sequence: DNPVFKSRSKKRKSSDDT | ||||||
Compositional bias | 972-1004 | Polar residues | ||||
Sequence: KISQDSSSPEHNLDSQDGSLTDHEFNTGTVKSP | ||||||
Compositional bias | 1018-1043 | Polar residues | ||||
Sequence: QRRPSMSSPNNSTNSTSTNSSSMAKG |
Sequence similarities
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,081
- Mass (Da)120,753
- Last updated2011-03-08 v1
- ChecksumF02DE03919A9484C
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8P4G513 | A0A8P4G513_DICLA | 1042 | |||
A0A8P4K2T3 | A0A8P4K2T3_DICLA | 926 | |||
A0A8P4KFF3 | A0A8P4KFF3_DICLA | 449 | |||
A0A8C4ITH2 | A0A8C4ITH2_DICLA | 880 | |||
A0A8C4IR91 | A0A8C4IR91_DICLA | 470 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 496-510 | Pro residues | ||||
Sequence: PPKPPKPPKMPKAPK | ||||||
Compositional bias | 512-531 | Basic and acidic residues | ||||
Sequence: PKVPKVKEGGKKKAKKVKES | ||||||
Compositional bias | 725-747 | Basic and acidic residues | ||||
Sequence: SSDEETLHIDTEAKPEVKSRNSK | ||||||
Compositional bias | 770-840 | Polar residues | ||||
Sequence: GIDYSTNSQPPASPSTQEAIQGMLSMANLSSSDSLQQPWSNSQSKNNSQSKSNSHGAQGGKKGSGGGGNNS | ||||||
Compositional bias | 851-874 | Basic and acidic residues | ||||
Sequence: PRKSSSIESLDYDDDQDHMDACFK | ||||||
Compositional bias | 888-905 | Basic and acidic residues | ||||
Sequence: DNPVFKSRSKKRKSSDDT | ||||||
Compositional bias | 972-1004 | Polar residues | ||||
Sequence: KISQDSSSPEHNLDSQDGSLTDHEFNTGTVKSP | ||||||
Compositional bias | 1018-1043 | Polar residues | ||||
Sequence: QRRPSMSSPNNSTNSTSTNSSSMAKG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FQ310506 EMBL· GenBank· DDBJ | CBN80631.1 EMBL· GenBank· DDBJ | Genomic DNA |