optively transferred wide-type B cells partially recovered B-cell activation and autoantibody production in SMS1 deficient bm12-induced lupus mice. Moreover the SMS1 mRNA level in B cells of SLE patients was increased and positively correlated with the serum anti-dsDNA level IgG and globulin titers.
The inhibition of SMS 1 activity induced CD cells to lose their epithelial phenotype and to undergo an epithelial-mesenchymal transition (EMT) process.
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