E6MVS4 · E6MVS4_NEIMH
- ProteinNa(+)-translocating NADH-quinone reductase subunit F
- GenenqrF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids405 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
Catalytic activity
- a ubiquinone + n Na+(in) + NADH + H+ = a ubiquinol + n Na+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + n Na+ (in)CHEBI:29101+ CHEBI:57945 + CHEBI:15378 = a ubiquinol RHEA-COMP:9566 + n Na+ (out)CHEBI:29101+ CHEBI:57540
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 67 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 73 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 76 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 108 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNa(+)-translocating NADH-quinone reductase subunit F
- EC number
- Short namesNa(+)-NQR subunit F ; Na(+)-translocating NQR subunit F
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionE6MVS4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-24 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length405
- Mass (Da)45,164
- Last updated2011-03-08 v1
- MD5 Checksum5CDD08D7DCFBDFA13E5AF2299F63F727
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AEQZ01000012 EMBL· GenBank· DDBJ | EFV64382.1 EMBL· GenBank· DDBJ | Genomic DNA |