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E6MVS4 · E6MVS4_NEIMH

Function

function

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site67[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site73[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site76[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site108[2Fe-2S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Functionelectron transfer activity
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Na(+)-translocating NADH-quinone reductase subunit F
  • EC number
  • Short names
    Na(+)-NQR subunit F
    ; Na(+)-translocating NQR subunit F
  • Alternative names
    • NQR complex subunit F
    • NQR-1 subunit F

Gene names

    • Name
      nqrF
    • ORF names
      NMH_0762

Organism names

Accessions

  • Primary accession
    E6MVS4

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical

Keywords

Interaction

Subunit

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-1242Fe-2S ferredoxin-type
Domain127-267FAD-binding FR-type

Sequence similarities

Belongs to the NqrF family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    45,164
  • Last updated
    2011-03-08 v1
  • MD5 Checksum
    5CDD08D7DCFBDFA13E5AF2299F63F727
MEIILGIVMFTVIVLVLALMILFAKSKLVSEGDITIKVNGEKELTMPAGGKLLGALANEGIFIPSACGGGGSCGQCRVVVKSGGGDILPTELSHISKREAREGCRLSCQVNVKTDMDIEVPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVPFRAGGYIQIEAPPHTVAYKDFDIPKEYHEDWDKYNLWQYVSKVDEPILRAYSMASYPEEKGIIMLNVRIATPPPRVPDAPPGQMSSYIWSLKPGDKVTISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLNSKRKITFWYGARSKREMFYVEDFDQLAAEFPNFTWHVALSDPLPEDNWDGYTGFIHNVVYENHLKNHEAPEDCEFYMCGPPIMNQSVIKMLKDLGVEDENILLDDFGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEQZ01000012
EMBL· GenBank· DDBJ
EFV64382.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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