E6MUU7 · E6MUU7_NEIMH

Function

function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).

Miscellaneous

The active site is located at the dimer interface.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 divalent metal cation per subunit. Can use ions such as Zn2+, Mg2+ or Co2+.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site137substrate
Binding site138substrate
Binding site167a divalent metal cation (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site212a divalent metal cation (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site267a divalent metal cation (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site275substrate
Binding site284substrate
Binding site293substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4-hydroxythreonine-4-phosphate dehydrogenase activity
Molecular Functioncobalt ion binding
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological Processpyridoxal phosphate biosynthetic process
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxythreonine-4-phosphate dehydrogenase
  • EC number
  • Alternative names
    • 4-(phosphohydroxy)-L-threonine dehydrogenase

Gene names

    • Name
      pdxA
    • ORF names
      NMH_0598

Organism names

Accessions

  • Primary accession
    E6MUU7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the PdxA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    330
  • Mass (Da)
    34,535
  • Last updated
    2011-03-08 v1
  • Checksum
    0CF6EB8EE045A834
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKNLLRARAEALGKSVVLRDFDPESGGASEEGVLEVLHIPAAEAVEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLNKGIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRVALVTTHLPLKDVAAAITQPLIESVARILHHDLKHKFGIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRREGINLAGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTALDLAATGRADSGSLITAVETAVEMARGSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEQZ01000010
EMBL· GenBank· DDBJ
EFV64668.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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