E6LHV4 · CSM4_ENTI1

Function

function

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. In a heterologous host the appropriately targeted Csm effector complex prevents growth of dsDNA phage phiNM1-gamma6.
The subunit probably binds to the 5' handle of the crRNA, helping in discrimination between self- and non-self.

Miscellaneous

Encoded in a type III-A CRISPR locus.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionRNA binding
Biological Processdefense response to virus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    CRISPR system Cms protein Csm4
  • Alternative names
    • CRISPR type III A-associated RAMP protein Csm4

Gene names

    • Name
      csm4
    • ORF names
      HMPREF9088_1944

Organism names

Accessions

  • Primary accession
    E6LHV4

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004461201-307CRISPR system Cms protein Csm4

Interaction

Subunit

Part of the Csm effector complex that includes Cas10, Csm2, Csm3, Csm4 and Csm5.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the CRISPR-associated Csm4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    34,316
  • Last updated
    2011-03-08 v1
  • Checksum
    5C0D52EC323B7AEC
MNQLVVKLVKLTFKSPVHFGMKRLSDSNHTIAADTLFSALIIEALQQQLELSHLLNNLVITDLFPYNKTSYFLPKPLIRIEGKKGDESGYKAFKKLTYIPVENYSEYLRGEIDSLEASKIAESLNLGKASLSTKVSLQAVDHNGESEPYSVGNFTFYPESGLYFLAKGNADTIGQLEILMHALQYSGIGGKRSAGYGQFRCTIEDSGKFDSLLSQTGNIAILLSSAMASDEELVDCLEDARYLLKKRTGFVQSKTYADQLVKKKDFYAFSAGSTFYQKFNGKIFDVSDNGRHSVYRYAKAFWLEGKI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEPV01000074
EMBL· GenBank· DDBJ
EFU73214.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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