E6KWD8 · E6KWD8_9PAST
- ProteinBifunctional chorismate mutase/prephenate dehydratase
- GenepheA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids387 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
Catalytic activity
- H+ + prephenate = 3-phenylpyruvate + CO2 + H2O
Pathway
Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.
Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | substrate | ||||
Sequence: R | ||||||
Binding site | 26 | substrate | ||||
Sequence: R | ||||||
Binding site | 37 | substrate | ||||
Sequence: K | ||||||
Binding site | 46 | substrate | ||||
Sequence: D | ||||||
Binding site | 50 | substrate | ||||
Sequence: E | ||||||
Binding site | 84 | substrate | ||||
Sequence: S | ||||||
Binding site | 88 | substrate | ||||
Sequence: Q | ||||||
Site | 278 | Essential for prephenate dehydratase activity | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | chorismate mutase activity | |
Molecular Function | prephenate dehydratase activity | |
Biological Process | chorismate metabolic process | |
Biological Process | L-phenylalanine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional chorismate mutase/prephenate dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Aggregatibacter
Accessions
- Primary accessionE6KWD8
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-92 | Chorismate mutase | ||||
Sequence: MSLDLSEIRQQITQIDRSLLKLLSERHRLAFDVVRSKELTQKPLRDAEREEQLLQELVQFAENENYQLEPQYITSIFQKIIEDSVLTQQVYL | ||||||
Domain | 105-285 | Prephenate dehydratase | ||||
Sequence: HIAFLGKRGSYSHLAARNYATRYQEELVEISCASFDEVFAKVQHGEADYGVLPLENTTSGAINEVYDLLQHTDLFLVGELAYPIQHCVLVNGQDDLSKIDTLYSHPQVIQQCSHFIHGLERVHIEYCESSSHAMQLVAGLNKPNIAALGNEDGGKLYGLNVLKRNVANQENNITRFIVIAK | ||||||
Domain | 299-376 | ACT | ||||
Sequence: LLLMSTGQQAGALVDALLVFKKHHINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTQSALEELKQFSHYLKILGCYP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length387
- Mass (Da)44,178
- Last updated2011-03-08 v1
- Checksum27D6A1AE0325BCF1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AEPS01000003 EMBL· GenBank· DDBJ | EFU67819.1 EMBL· GenBank· DDBJ | Genomic DNA |