E5RHP6 · E5RHP6_HUMAN

  • Protein
    Pro-neuregulin-1, membrane-bound isoform
  • Gene
    NRG1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionsignaling receptor binding
Biological Processnervous system development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pro-neuregulin-1, membrane-bound isoform

Gene names

    • Name
      NRG1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E5RHP6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane89-111Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 335 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond58↔67

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain24-68EGF-like
Region180-206Disordered
Compositional bias221-235Polar residues
Region221-243Disordered

Sequence similarities

Belongs to the neuregulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    34,404
  • Last updated
    2023-09-13 v9
  • Checksum
    915B562729A4339C
MQIPKHISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL

Computationally mapped potential isoform sequences

There are 19 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q02297NRG1_HUMANNRG1640
H0YDC2H0YDC2_HUMANNRG1236
H0YCP0H0YCP0_HUMANNRG1126
H0YBA3H0YBA3_HUMANNRG1713
A0A494BZT4A0A494BZT4_HUMANNRG1214
A0A5F9ZHA5A0A5F9ZHA5_HUMANNRG1168
A0A494C1G2A0A494C1G2_HUMANNRG1387
A0A494C1F5A0A494C1F5_HUMANNRG1624
A0A494C1F8A0A494C1F8_HUMANNRG1607
A0A494C1B5A0A494C1B5_HUMANNRG1483
A0A494C0L9A0A494C0L9_HUMANNRG1522
A0A494C0K4A0A494C0K4_HUMANNRG1459
A0A494C0Q4A0A494C0Q4_HUMANNRG1700
A0A494C0T5A0A494C0T5_HUMANNRG1130
A0A494C114A0A494C114_HUMANNRG1207
A0A494C054A0A494C054_HUMANNRG1155
A0A494C043A0A494C043_HUMANNRG1461
E5RIG8E5RIG8_HUMANNRG1135
E5RHQ1E5RHQ1_HUMANNRG1101

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias221-235Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC021909
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC022833
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC022850
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC023948
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC068931
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC104000
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC104029
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458727
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458729
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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