E5N5Y6 · E5N5Y6_PARFO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    E5N5Y6
  • Secondary accessions
    • A0A4P1U0Z7

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-217Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    217
  • Mass (Da)
    23,117
  • Last updated
    2011-05-03 v1
  • Checksum
    17700C6968578434
LYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue217

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU673805
EMBL· GenBank· DDBJ
ADH23464.1
EMBL· GenBank· DDBJ
Genomic DNA
GU674322
EMBL· GenBank· DDBJ
ADH23981.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ561521
EMBL· GenBank· DDBJ
ADR02128.1
EMBL· GenBank· DDBJ
Genomic DNA
JN313103
EMBL· GenBank· DDBJ
AEM15703.1
EMBL· GenBank· DDBJ
Genomic DNA
JN313127
EMBL· GenBank· DDBJ
AEM15727.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ350169
EMBL· GenBank· DDBJ
AFA55709.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ350170
EMBL· GenBank· DDBJ
AFA55710.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ350171
EMBL· GenBank· DDBJ
AFA55711.1
EMBL· GenBank· DDBJ
Genomic DNA
KF489690
EMBL· GenBank· DDBJ
AGZ03294.1
EMBL· GenBank· DDBJ
Genomic DNA
KP194317
EMBL· GenBank· DDBJ
AKE99364.1
EMBL· GenBank· DDBJ
Genomic DNA
KP194651
EMBL· GenBank· DDBJ
AKE99698.1
EMBL· GenBank· DDBJ
Genomic DNA
KU176429
EMBL· GenBank· DDBJ
ANP25963.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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