E5KPM9 · E5KPM9_HUMAN

  • Protein
    DNA-(apurinic or apyrimidinic site) lyase
  • Gene
    OGG1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Molecular Function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondamaged DNA binding
Biological Processbase-excision repair, AP site formation
Biological Processnucleotide-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) lyase
  • EC number

Gene names

    • Name
      OGG1
    • ORF names
      hCG_20369

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E5KPM9

Organism-specific databases

Subcellular Location

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain146-316HhH-GPD

Sequence similarities

Belongs to the type-1 OGG1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    36,085
  • Last updated
    2011-02-08 v1
  • Checksum
    E47B3CA5AE8CFABB
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAAGSDAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ205506
EMBL· GenBank· DDBJ
ADQ20121.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205507
EMBL· GenBank· DDBJ
ADQ20128.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205508
EMBL· GenBank· DDBJ
ADQ20135.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205509
EMBL· GenBank· DDBJ
ADQ20142.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205510
EMBL· GenBank· DDBJ
ADQ20149.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205511
EMBL· GenBank· DDBJ
ADQ20156.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205512
EMBL· GenBank· DDBJ
ADQ20163.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205513
EMBL· GenBank· DDBJ
ADQ20170.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205514
EMBL· GenBank· DDBJ
ADQ20177.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205515
EMBL· GenBank· DDBJ
ADQ20184.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205516
EMBL· GenBank· DDBJ
ADQ20191.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205517
EMBL· GenBank· DDBJ
ADQ20198.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205518
EMBL· GenBank· DDBJ
ADQ20205.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205519
EMBL· GenBank· DDBJ
ADQ20212.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205520
EMBL· GenBank· DDBJ
ADQ20219.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205521
EMBL· GenBank· DDBJ
ADQ20226.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205522
EMBL· GenBank· DDBJ
ADQ20233.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205523
EMBL· GenBank· DDBJ
ADQ20240.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205524
EMBL· GenBank· DDBJ
ADQ20247.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205525
EMBL· GenBank· DDBJ
ADQ20254.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205526
EMBL· GenBank· DDBJ
ADQ20261.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205527
EMBL· GenBank· DDBJ
ADQ20268.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205528
EMBL· GenBank· DDBJ
ADQ20275.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205529
EMBL· GenBank· DDBJ
ADQ20282.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205530
EMBL· GenBank· DDBJ
ADQ20289.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205531
EMBL· GenBank· DDBJ
ADQ20296.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205532
EMBL· GenBank· DDBJ
ADQ20303.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205533
EMBL· GenBank· DDBJ
ADQ20310.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205534
EMBL· GenBank· DDBJ
ADQ20317.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205535
EMBL· GenBank· DDBJ
ADQ20324.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205536
EMBL· GenBank· DDBJ
ADQ20331.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205537
EMBL· GenBank· DDBJ
ADQ20338.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205538
EMBL· GenBank· DDBJ
ADQ20345.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205539
EMBL· GenBank· DDBJ
ADQ20352.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205540
EMBL· GenBank· DDBJ
ADQ20359.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205541
EMBL· GenBank· DDBJ
ADQ20366.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205542
EMBL· GenBank· DDBJ
ADQ20373.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205543
EMBL· GenBank· DDBJ
ADQ20380.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205544
EMBL· GenBank· DDBJ
ADQ20387.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205545
EMBL· GenBank· DDBJ
ADQ20394.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471055
EMBL· GenBank· DDBJ
EAW63985.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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