E5KPM9 · E5KPM9_HUMAN
- ProteinDNA-(apurinic or apyrimidinic site) lyase
- GeneOGG1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids322 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Catalytic activity
- 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Molecular Function | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | |
Molecular Function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | damaged DNA binding | |
Biological Process | base-excision repair, AP site formation | |
Biological Process | nucleotide-excision repair |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA-(apurinic or apyrimidinic site) lyase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE5KPM9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 146-316 | HhH-GPD | ||||
Sequence: CSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQA |
Sequence similarities
Belongs to the type-1 OGG1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length322
- Mass (Da)36,085
- Last updated2011-02-08 v1
- ChecksumE47B3CA5AE8CFABB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HQ205506 EMBL· GenBank· DDBJ | ADQ20121.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205507 EMBL· GenBank· DDBJ | ADQ20128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205508 EMBL· GenBank· DDBJ | ADQ20135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205509 EMBL· GenBank· DDBJ | ADQ20142.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205510 EMBL· GenBank· DDBJ | ADQ20149.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205511 EMBL· GenBank· DDBJ | ADQ20156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205512 EMBL· GenBank· DDBJ | ADQ20163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205513 EMBL· GenBank· DDBJ | ADQ20170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205514 EMBL· GenBank· DDBJ | ADQ20177.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205515 EMBL· GenBank· DDBJ | ADQ20184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205516 EMBL· GenBank· DDBJ | ADQ20191.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205517 EMBL· GenBank· DDBJ | ADQ20198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205518 EMBL· GenBank· DDBJ | ADQ20205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205519 EMBL· GenBank· DDBJ | ADQ20212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205520 EMBL· GenBank· DDBJ | ADQ20219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205521 EMBL· GenBank· DDBJ | ADQ20226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205522 EMBL· GenBank· DDBJ | ADQ20233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205523 EMBL· GenBank· DDBJ | ADQ20240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205524 EMBL· GenBank· DDBJ | ADQ20247.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205525 EMBL· GenBank· DDBJ | ADQ20254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205526 EMBL· GenBank· DDBJ | ADQ20261.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205527 EMBL· GenBank· DDBJ | ADQ20268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205528 EMBL· GenBank· DDBJ | ADQ20275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205529 EMBL· GenBank· DDBJ | ADQ20282.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205530 EMBL· GenBank· DDBJ | ADQ20289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205531 EMBL· GenBank· DDBJ | ADQ20296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205532 EMBL· GenBank· DDBJ | ADQ20303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205533 EMBL· GenBank· DDBJ | ADQ20310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205534 EMBL· GenBank· DDBJ | ADQ20317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205535 EMBL· GenBank· DDBJ | ADQ20324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205536 EMBL· GenBank· DDBJ | ADQ20331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205537 EMBL· GenBank· DDBJ | ADQ20338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205538 EMBL· GenBank· DDBJ | ADQ20345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205539 EMBL· GenBank· DDBJ | ADQ20352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205540 EMBL· GenBank· DDBJ | ADQ20359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205541 EMBL· GenBank· DDBJ | ADQ20366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205542 EMBL· GenBank· DDBJ | ADQ20373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205543 EMBL· GenBank· DDBJ | ADQ20380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205544 EMBL· GenBank· DDBJ | ADQ20387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205545 EMBL· GenBank· DDBJ | ADQ20394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471055 EMBL· GenBank· DDBJ | EAW63985.1 EMBL· GenBank· DDBJ | Genomic DNA |