The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age TNF-alpha and waist circumference in healthy adults.
8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-kappaB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276.
Association of base excision repair pathway genes OGG1 XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence.
OGG1 contributes to hepatocellular carcinoma by promoting cell cycle-related protein expression and enhancing DNA oxidative damage repair in tumor cells.
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