Expression of APC is decreased in mutation negative cases and this appears to be a promising indicator of FAP predisposition while for MUTYH gene mutation is associated to reduced mRNA expression.
APC or MUTYH mutations were detected in 42/48 (88%) 14/20 (70%) and 10/38 (26%) of familial adenomatous polyposis attenuated familial adenomatous polyposis and multiple colorectal adenomas patients respectively.
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