E5KP27 · E5KP27_HUMAN

  • Protein
    Adenine DNA glycosylase
  • Gene
    MUTYH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Adenine glycosylase active on G-A mispairs.

Catalytic activity

  • Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
    EC:3.2.2.31 (UniProtKB | ENZYME | Rhea)

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionpurine-specific mismatch base pair DNA N-glycosylase activity
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine DNA glycosylase
  • EC number

Gene names

    • Name
      MUTYH
    • ORF names
      hCG_1780049

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E5KP27

Organism-specific databases

Subcellular Location

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region19-52Disordered
Compositional bias36-50Polar residues
Domain353-484Nudix hydrolase

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    535
  • Mass (Da)
    59,071
  • Last updated
    2011-02-08 v1
  • MD5 Checksum
    72497945E790D6D6D27BC5E902ACC43F
MTPLVSRLSRLWAIMRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACDGLARQPEEVVLQASVSSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLSGSPDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHSLNSAAQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias36-50Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ205466
EMBL· GenBank· DDBJ
ADP90934.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205468
EMBL· GenBank· DDBJ
ADP90944.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205469
EMBL· GenBank· DDBJ
ADP90949.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205470
EMBL· GenBank· DDBJ
ADP90954.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205472
EMBL· GenBank· DDBJ
ADP90964.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205473
EMBL· GenBank· DDBJ
ADP90969.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205474
EMBL· GenBank· DDBJ
ADP90974.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205475
EMBL· GenBank· DDBJ
ADP90979.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205476
EMBL· GenBank· DDBJ
ADP90984.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205477
EMBL· GenBank· DDBJ
ADP90989.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205479
EMBL· GenBank· DDBJ
ADP90999.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205480
EMBL· GenBank· DDBJ
ADP91004.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205481
EMBL· GenBank· DDBJ
ADP91009.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205482
EMBL· GenBank· DDBJ
ADP91014.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205483
EMBL· GenBank· DDBJ
ADP91019.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205484
EMBL· GenBank· DDBJ
ADP91024.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205485
EMBL· GenBank· DDBJ
ADP91029.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205486
EMBL· GenBank· DDBJ
ADP91034.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205487
EMBL· GenBank· DDBJ
ADP91039.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205488
EMBL· GenBank· DDBJ
ADP91044.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205489
EMBL· GenBank· DDBJ
ADP91049.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205490
EMBL· GenBank· DDBJ
ADP91054.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205491
EMBL· GenBank· DDBJ
ADP91059.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205492
EMBL· GenBank· DDBJ
ADP91064.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205493
EMBL· GenBank· DDBJ
ADP91069.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205494
EMBL· GenBank· DDBJ
ADP91074.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205495
EMBL· GenBank· DDBJ
ADP91079.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205496
EMBL· GenBank· DDBJ
ADP91084.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205497
EMBL· GenBank· DDBJ
ADP91089.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205498
EMBL· GenBank· DDBJ
ADP91094.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205499
EMBL· GenBank· DDBJ
ADP91099.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205500
EMBL· GenBank· DDBJ
ADP91104.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205501
EMBL· GenBank· DDBJ
ADP91109.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205502
EMBL· GenBank· DDBJ
ADP91114.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205503
EMBL· GenBank· DDBJ
ADP91119.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205505
EMBL· GenBank· DDBJ
ADP91129.1
EMBL· GenBank· DDBJ
Genomic DNA
KU178203
EMBL· GenBank· DDBJ
ALQ33661.1
EMBL· GenBank· DDBJ
mRNA
CH471059
EMBL· GenBank· DDBJ
EAX06994.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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