E5KP25 · E5KP25_HUMAN

  • Protein
    Adenine DNA glycosylase
  • Gene
    MUTYH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Adenine glycosylase active on G-A mispairs.

Catalytic activity

  • Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
    EC:3.2.2.31 (UniProtKB | ENZYME | Rhea)

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionpurine-specific mismatch base pair DNA N-glycosylase activity
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine DNA glycosylase
  • EC number

Gene names

    • Name
      MUTYH

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    E5KP25

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,521 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region19-47Disordered
Domain367-498Nudix hydrolase

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    549
  • Mass (Da)
    60,315
  • Last updated
    2011-02-08 v1
  • MD5 Checksum
    DEA0B2831F05C9E744A7BD4311AFDCB8
MTPLVSRLSRLWAIMRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACDACAGMIAECPGAPAGLARQPEEVVLQASVSSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLSGSPDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHSLNSAAQ

Computationally mapped potential isoform sequences

There are 21 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9UIF7MUTYH_HUMANMUTYH546
A0AAQ5BGW7A0AAQ5BGW7_HUMANMUTYH528
A0A6Q8PF38A0A6Q8PF38_HUMANMUTYH47
H0YEI2H0YEI2_HUMANMUTYH386
H0YER6H0YER6_HUMANMUTYH97
H0YCY5H0YCY5_HUMANMUTYH472
H0YCA8H0YCA8_HUMANMUTYH478
Q5T413Q5T413_HUMANMUTYH291
Q5T418Q5T418_HUMANMUTYH393
A0A5F9ZHI2A0A5F9ZHI2_HUMANMUTYH212
A0A5F9ZI14A0A5F9ZI14_HUMANMUTYH466
A0A5F9ZI60A0A5F9ZI60_HUMANMUTYH209
E9PNY0E9PNY0_HUMANMUTYH216
E9PP30E9PP30_HUMANMUTYH45
E9PP34E9PP34_HUMANMUTYH527
E9PLT4E9PLT4_HUMANMUTYH62
E9PM53E9PM53_HUMANMUTYH535
E9PMH1E9PMH1_HUMANMUTYH185
E9PIW5E9PIW5_HUMANMUTYH40
E9PKM9E9PKM9_HUMANMUTYH55
E9PI11E9PI11_HUMANMUTYH54

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL359540
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
HQ205466
EMBL· GenBank· DDBJ
ADP90936.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205468
EMBL· GenBank· DDBJ
ADP90946.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205469
EMBL· GenBank· DDBJ
ADP90951.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205470
EMBL· GenBank· DDBJ
ADP90956.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205472
EMBL· GenBank· DDBJ
ADP90966.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205473
EMBL· GenBank· DDBJ
ADP90971.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205474
EMBL· GenBank· DDBJ
ADP90976.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205475
EMBL· GenBank· DDBJ
ADP90981.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205476
EMBL· GenBank· DDBJ
ADP90986.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205477
EMBL· GenBank· DDBJ
ADP90991.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205479
EMBL· GenBank· DDBJ
ADP91001.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205480
EMBL· GenBank· DDBJ
ADP91006.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205481
EMBL· GenBank· DDBJ
ADP91011.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205482
EMBL· GenBank· DDBJ
ADP91016.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205483
EMBL· GenBank· DDBJ
ADP91021.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205484
EMBL· GenBank· DDBJ
ADP91026.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205485
EMBL· GenBank· DDBJ
ADP91031.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205486
EMBL· GenBank· DDBJ
ADP91036.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205487
EMBL· GenBank· DDBJ
ADP91041.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205488
EMBL· GenBank· DDBJ
ADP91046.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205489
EMBL· GenBank· DDBJ
ADP91051.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205490
EMBL· GenBank· DDBJ
ADP91056.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205491
EMBL· GenBank· DDBJ
ADP91061.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205492
EMBL· GenBank· DDBJ
ADP91066.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205493
EMBL· GenBank· DDBJ
ADP91071.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205494
EMBL· GenBank· DDBJ
ADP91076.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205495
EMBL· GenBank· DDBJ
ADP91081.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205496
EMBL· GenBank· DDBJ
ADP91086.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205497
EMBL· GenBank· DDBJ
ADP91091.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205498
EMBL· GenBank· DDBJ
ADP91096.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205499
EMBL· GenBank· DDBJ
ADP91101.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205500
EMBL· GenBank· DDBJ
ADP91106.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205501
EMBL· GenBank· DDBJ
ADP91111.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205502
EMBL· GenBank· DDBJ
ADP91116.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205503
EMBL· GenBank· DDBJ
ADP91121.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ205505
EMBL· GenBank· DDBJ
ADP91131.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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