E5KMT5 · E5KMT5_HUMAN
- ProteinMitochondrial tRNA pseudouridine synthase A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids427 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 146 | Nucleophile | ||||
Sequence: D | ||||||
Binding site | 201 | substrate | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleoplasm | |
Molecular Function | pseudouridine synthase activity | |
Molecular Function | RNA binding | |
Biological Process | mRNA pseudouridine synthesis | |
Biological Process | tRNA pseudouridine synthesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionE5KMT5
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-83 | Disordered | ||||
Sequence: GPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPK | ||||||
Compositional bias | 50-83 | Basic and acidic residues | ||||
Sequence: SGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPK | ||||||
Domain | 239-341 | Pseudouridine synthase I TruA alpha/beta | ||||
Sequence: YKGTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFE | ||||||
Region | 407-427 | Disordered | ||||
Sequence: GGTGAKVPSPLEGSEGDGDTD |
Sequence similarities
Belongs to the tRNA pseudouridine synthase TruA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)47,470
- Last updated2011-02-08 v1
- ChecksumACE9FA6AE0F178BA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 50-83 | Basic and acidic residues | ||||
Sequence: SGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPK |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HQ205066 EMBL· GenBank· DDBJ | ADP90494.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205067 EMBL· GenBank· DDBJ | ADP90496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205068 EMBL· GenBank· DDBJ | ADP90498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205069 EMBL· GenBank· DDBJ | ADP90500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205070 EMBL· GenBank· DDBJ | ADP90502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205071 EMBL· GenBank· DDBJ | ADP90504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205072 EMBL· GenBank· DDBJ | ADP90506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205073 EMBL· GenBank· DDBJ | ADP90508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205074 EMBL· GenBank· DDBJ | ADP90510.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205075 EMBL· GenBank· DDBJ | ADP90512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205076 EMBL· GenBank· DDBJ | ADP90514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205077 EMBL· GenBank· DDBJ | ADP90516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205078 EMBL· GenBank· DDBJ | ADP90518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205079 EMBL· GenBank· DDBJ | ADP90520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205080 EMBL· GenBank· DDBJ | ADP90522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205081 EMBL· GenBank· DDBJ | ADP90524.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205082 EMBL· GenBank· DDBJ | ADP90526.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205083 EMBL· GenBank· DDBJ | ADP90528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205084 EMBL· GenBank· DDBJ | ADP90530.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205085 EMBL· GenBank· DDBJ | ADP90532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205086 EMBL· GenBank· DDBJ | ADP90534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205087 EMBL· GenBank· DDBJ | ADP90536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205088 EMBL· GenBank· DDBJ | ADP90538.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205089 EMBL· GenBank· DDBJ | ADP90540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205090 EMBL· GenBank· DDBJ | ADP90542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205091 EMBL· GenBank· DDBJ | ADP90544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205092 EMBL· GenBank· DDBJ | ADP90546.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205093 EMBL· GenBank· DDBJ | ADP90548.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205094 EMBL· GenBank· DDBJ | ADP90550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205095 EMBL· GenBank· DDBJ | ADP90552.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205096 EMBL· GenBank· DDBJ | ADP90554.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205097 EMBL· GenBank· DDBJ | ADP90556.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205098 EMBL· GenBank· DDBJ | ADP90558.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205099 EMBL· GenBank· DDBJ | ADP90560.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205100 EMBL· GenBank· DDBJ | ADP90562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205101 EMBL· GenBank· DDBJ | ADP90564.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205102 EMBL· GenBank· DDBJ | ADP90566.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205103 EMBL· GenBank· DDBJ | ADP90568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205104 EMBL· GenBank· DDBJ | ADP90570.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ205105 EMBL· GenBank· DDBJ | ADP90572.1 EMBL· GenBank· DDBJ | Genomic DNA |