E5KHU9 · E5KHU9_9ASTR
- ProteinSqualene synthase
- GeneSQS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids173 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.
Catalytic activity
- 2 (2E,6E)-farnesyl diphosphate + H+ + NADH = 2 diphosphate + NAD+ + squaleneThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Pathway
Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | farnesyl-diphosphate farnesyltransferase activity | |
Molecular Function | farnesyltranstransferase activity | |
Molecular Function | squalene synthase activity | |
Biological Process | isoprenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSqualene synthase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Asterales > Asteraceae > Cichorioideae > Cichorieae > Hieraciinae > Hieracium
Accessions
- Primary accessionE5KHU9
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length173
- Mass (Da)19,862
- Last updated2011-02-08 v1
- ChecksumF6CA3ECD6AA0410D
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: H | ||||||
Non-terminal residue | 173 | |||||
Sequence: T |