E5DCW3 · E5DCW3_ACROI
- ProteinCytochrome b
- Genecytb
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids346 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 50 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 64 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 149 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 163 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 168 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Sylvioidea > Sylviidae > Acrocephalinae > Acrocephalus
Accessions
- Primary accessionE5DCW3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-37 | Helical | ||||
Sequence: IVTGLLLAMHYTADTSLAFASVAHVC | ||||||
Transmembrane | 49-70 | Helical | ||||
Sequence: LHANGASFFFICIYFHIGRGFY | ||||||
Transmembrane | 82-100 | Helical | ||||
Sequence: IGVVLLLTLMATAFVGYVL | ||||||
Transmembrane | 107-125 | Helical | ||||
Sequence: FWGATVITNLFSAIPYIGQ | ||||||
Transmembrane | 145-167 | Helical | ||||
Sequence: FFALHFLLPFVIAGLTLVHLTLL | ||||||
Transmembrane | 196-217 | Helical | ||||
Sequence: ILGFAFMFILLASLALFSPNLL | ||||||
Transmembrane | 255-274 | Helical | ||||
Sequence: LGGVLALAASVLVLFLMPLL | ||||||
Transmembrane | 286-307 | Helical | ||||
Sequence: PLSQILFWALVANLLVLTWVGS | ||||||
Transmembrane | 313-339 | Helical | ||||
Sequence: PFIIIGQLASLSYFTIILVLFPLASIF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-176 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: GSLLGVCLVTQIVTGLLLAMHYTADTSLAFASVAHVCRDVQFGWLIRNLHANGASFFFICIYFHIGRGFYYGSYLNKETWNIGVVLLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIAGLTLVHLTLLHETGSNNPL | ||||||
Domain | 177-346 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GIPSDCDKIPFHPYYSVKDILGFAFMFILLASLALFSPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLMPLLHTSKLRSMTFRPLSQILFWALVANLLVLTWVGSQPVEHPFIIIGQLASLSYFTIILVLFPLASIFENKLLKL |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length346
- Mass (Da)38,421
- Last updated2011-02-08 v1
- ChecksumAD70403359A93543
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: G | ||||||
Non-terminal residue | 346 | |||||
Sequence: L |