E4ZUB5 · LCPS_LEPMJ
- ProteinBifunctional lycopene cyclase/phytoene synthase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids581 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).
Catalytic activity
- all-trans-lycopene = gamma-carotene
Pathway
Carotenoid biosynthesis; beta-carotene biosynthesis.
Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 15-cis-phytoene synthase activity | |
Molecular Function | farnesyl-diphosphate farnesyltransferase activity | |
Molecular Function | farnesyltranstransferase activity | |
Molecular Function | geranylgeranyl-diphosphate geranylgeranyltransferase activity | |
Molecular Function | intramolecular lyase activity | |
Molecular Function | lycopene beta cyclase activity | |
Biological Process | carotenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional lycopene cyclase/phytoene synthase
Including 2 domains:
- Recommended nameLycopene beta-cyclase
- EC number
- Alternative names
- Recommended namePhytoene synthase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Leptosphaeriaceae > Plenodomus > Plenodomus lingam/Leptosphaeria maculans species complex
Accessions
- Primary accessionE4ZUB5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 3-23 | Helical | ||||
Sequence: FDYALVHLKYTIPPAVLLTLL | ||||||
Transmembrane | 35-55 | Helical | ||||
Sequence: KVAFLVTIAVVATIPWDSYLI | ||||||
Transmembrane | 65-85 | Helical | ||||
Sequence: HVIIGPTLFDIPLEEVFFFVV | ||||||
Transmembrane | 120-140 | Helical | ||||
Sequence: LKRLIGQAILLGAIAWGWFCV | ||||||
Transmembrane | 152-172 | Helical | ||||
Sequence: ILIWAGPFLLLLWSLAYQFII | ||||||
Transmembrane | 173-193 | Helical | ||||
Sequence: GLPFTNTLLPIVLPTLYLWIV | ||||||
Transmembrane | 221-241 | Helical | ||||
Sequence: IEEALFFLLTNVLIVFGQLAF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000409237 | 1-581 | Bifunctional lycopene cyclase/phytoene synthase | |||
Sequence: MGFDYALVHLKYTIPPAVLLTLLYRPLLTKIDVYKVAFLVTIAVVATIPWDSYLIRNRIWSYPDHVIIGPTLFDIPLEEVFFFVVQTYNTSLLYLVLSKPTFQPVYLCTERDELHGSWRLKRLIGQAILLGAIAWGWFCVRERGLGTYTGLILIWAGPFLLLLWSLAYQFIIGLPFTNTLLPIVLPTLYLWIVDTLALRRGTWVISPGTKFGVHLWDGLEIEEALFFLLTNVLIVFGQLAFDNALAVLYAFPHLFPDPSLLPSPATLIRSLLTSCAQYDEARLTGFREAVSRLKRKSRSFYLASSTFQGPLRMDLLLLYSFCRVADDLVDNAATTEEARQWIAKLHKFLDNVYRKDVVCSSVTDQVRKEFPLDTHSALLQLPCCKLSAEPLRDLLRGFEMDLEFNSTSPIQSTEDLVLYSERVAGTVAQMCIQLIFHLYPSSLTAEKRHKVVAAGNSMGVALQYVNIARDIGVDAKIGRVYLPTDWLSEVGLNCDTVLKDPKDPRIEALRGRLLDDAFSFYEEAKLAIAQLPIEAQGPIRVAVESYMEIGRTLKQDGFIVKAGRATVPKWRRVLVAWRTLN |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-243 | Lycopene beta-cyclase | ||||
Sequence: MGFDYALVHLKYTIPPAVLLTLLYRPLLTKIDVYKVAFLVTIAVVATIPWDSYLIRNRIWSYPDHVIIGPTLFDIPLEEVFFFVVQTYNTSLLYLVLSKPTFQPVYLCTERDELHGSWRLKRLIGQAILLGAIAWGWFCVRERGLGTYTGLILIWAGPFLLLLWSLAYQFIIGLPFTNTLLPIVLPTLYLWIVDTLALRRGTWVISPGTKFGVHLWDGLEIEEALFFLLTNVLIVFGQLAFDN | ||||||
Region | 250-581 | Phytoene synthase | ||||
Sequence: AFPHLFPDPSLLPSPATLIRSLLTSCAQYDEARLTGFREAVSRLKRKSRSFYLASSTFQGPLRMDLLLLYSFCRVADDLVDNAATTEEARQWIAKLHKFLDNVYRKDVVCSSVTDQVRKEFPLDTHSALLQLPCCKLSAEPLRDLLRGFEMDLEFNSTSPIQSTEDLVLYSERVAGTVAQMCIQLIFHLYPSSLTAEKRHKVVAAGNSMGVALQYVNIARDIGVDAKIGRVYLPTDWLSEVGLNCDTVLKDPKDPRIEALRGRLLDDAFSFYEEAKLAIAQLPIEAQGPIRVAVESYMEIGRTLKQDGFIVKAGRATVPKWRRVLVAWRTLN |
Sequence similarities
In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length581
- Mass (Da)65,807
- Last updated2011-02-08 v1
- ChecksumAE5B91B31A0FBDD1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FP929126 EMBL· GenBank· DDBJ | CBX94994.1 EMBL· GenBank· DDBJ | Genomic DNA |