E4WYW3 · E4WYW3_OIKDI

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site19-25GTP (UniProtKB | ChEBI)
Active site20Proton acceptor
Binding site20Mg2+ (UniProtKB | ChEBI)
Binding site20-23IMP (UniProtKB | ChEBI)
Binding site45-48IMP (UniProtKB | ChEBI)
Binding site47Mg2+ (UniProtKB | ChEBI)
Binding site47-49GTP (UniProtKB | ChEBI)
Active site48Proton donor
Binding site137IMP (UniProtKB | ChEBI)
Active site148
Binding site151IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site231IMP (UniProtKB | ChEBI)
Binding site246IMP (UniProtKB | ChEBI)
Binding site306-312substrate
Binding site310IMP (UniProtKB | ChEBI)
Binding site312GTP (UniProtKB | ChEBI)
Binding site338-340GTP (UniProtKB | ChEBI)
Binding site422-424GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      GSOID_T00013656001

Organism names

Accessions

  • Primary accession
    E4WYW3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    48,668
  • Last updated
    2011-02-08 v1
  • Checksum
    182D9E88CF4152D9
MNRRAPRNKVSVVLGAQWGDEGKGKLVDLLAVGMDVTARCAGGNNAGHTVICDGIKYDFHLLPSGITHEKSKALMGPGMVIHLPGLFAEIENNVEKGLKNWEDRLLISDRAHLVMDYHQALDAGNESRKGDKAIGTTKKGIGPTYANKASRTGVRVGDLVNNFEGFVERIRAGAQVAMLNLPGLDIDIDAEIARYKEYAVKIRPLVVDSVAWLTERTRSAEEINILVEGANATMLDLDHGTYPFVTSSSCSIGGVCTGLGLPPCAVGDVFGVAKAYCTRVGGGPFPTELENEIGEKLQKQGGEFGVTTGRPRRCGWLDLMQLDYADQINHFTALAITKLDVMDNFETVKVCVAYKNSETGDKVSCMPGQIKQLSQVVPVYKEFPGWMSDTTKCEKWESLPEKAKTYINFLEKSLKVPIRWIGVGPARESIVFRSREVSFANTGVEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN653019
EMBL· GenBank· DDBJ
CBY22879.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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