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E4Q1K8 · E4Q1K8_CALOW

Function

function

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site24-26substrate
Binding site40substrate
Binding site63-66substrate
Binding site122substrate
Binding site155substrate
Binding site205ATP (UniProtKB | ChEBI)
Binding site296ATP (UniProtKB | ChEBI)
Binding site327ATP (UniProtKB | ChEBI)
Binding site357-360ATP (UniProtKB | ChEBI)
Binding site411-413substrate
Active site496Electrophile
Active site568Proton acceptor
Binding site574substrate
Binding site614substrate
Binding site635-636substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionADP binding
Molecular FunctionATP binding
Molecular Functionphosphoglycerate kinase activity
Molecular Functiontriose-phosphate isomerase activity
Biological Processgluconeogenesis
Biological Processglycolytic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Triosephosphate isomerase
  • EC number
  • Short names
    TIM
    ; TPI
  • Alternative names
    • Triose-phosphate isomerase
  • Recommended name
    Phosphoglycerate kinase
  • EC number

Gene names

    • Name
      tpiA
    • Synonyms
      pgk
    • Ordered locus names
      Calow_1184

Organism names

Accessions

  • Primary accession
    E4Q1K8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.
Monomer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the phosphoglycerate kinase family.
Belongs to the triosephosphate isomerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    650
  • Mass (Da)
    70,983
  • Last updated
    2011-02-08 v1
  • MD5 Checksum
    0E95B64BED5C53F9B0BAB774BB572637
MPKLNKKTIRDIDVAGKRVLVRVDFNVPQDENGNITDDRRIKEALPTIKYLIDHNAKVILVSHLGRPKGKFDPKYSMAPVAKRLSELLGKEVVLAKDVIGDDAKKCVAQMKEGDVVLLENVRFHKEEEENDREFAKALASVADIYVNDAFGTAHRAHASTAGVAEFLPAVAGFLMEKEIEMLGNALANPQRPFVAILGGAKVSDKIGVIMNLLEKVDSLLIGGAMAYTFLKAKGYKIGKSKCEDDKLDVAREIMKKAEEKGVNLLLPVGSIVAKEFKNDTEFMYVPSDAMPDDMMGMDIGNTTIELFSKEIKKAKTIVWNGPMGVFEFPNFAKGTEAIARAVAEAVEENGAIAIIGGGDSAAAVEKLGFADKMTHISTGGGASLEFLEGKVLPGIACLLDKNPRKKIIAANWKMNKTPQEAKEFVEELKKYIDDVQAEVVICAPSILVPYVKEAIEGTNIKLGTQNMFYEEKGAYTGEISGPMLKEVGVEYVVIGHSERRQYFGETDEIVNKKVLAALKFGIKPIVCVGETLKQREYGITDELVRLQVKIALNGVSKEDVEKVVIAYEPIWAIGTGKNATPEEANRVIGVIRKVIAEIYDEDTAQKVRIQYGGSVNSANSAEIFNMPEIDGGLVGGASLNAQEFAKILHY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002216
EMBL· GenBank· DDBJ
ADQ04742.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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