E4Q1K8 · E4Q1K8_CALOW
- ProteinMultifunctional fusion protein
- GenetpiA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids650 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Catalytic activity
- (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 24-26 | substrate | |||
Binding site | 40 | substrate | |||
Binding site | 63-66 | substrate | |||
Binding site | 122 | substrate | |||
Binding site | 155 | substrate | |||
Binding site | 205 | ATP (UniProtKB | ChEBI) | |||
Binding site | 296 | ATP (UniProtKB | ChEBI) | |||
Binding site | 327 | ATP (UniProtKB | ChEBI) | |||
Binding site | 357-360 | ATP (UniProtKB | ChEBI) | |||
Binding site | 411-413 | substrate | |||
Active site | 496 | Electrophile | |||
Active site | 568 | Proton acceptor | |||
Binding site | 574 | substrate | |||
Binding site | 614 | substrate | |||
Binding site | 635-636 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ADP binding | |
Molecular Function | ATP binding | |
Molecular Function | phosphoglycerate kinase activity | |
Molecular Function | triose-phosphate isomerase activity | |
Biological Process | gluconeogenesis | |
Biological Process | glycolytic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameTriosephosphate isomerase
- EC number
- Short namesTIM ; TPI
- Alternative names
- Recommended namePhosphoglycerate kinase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacillota incertae sedis > Caldicellulosiruptorales > Caldicellulosiruptoraceae > Caldicellulosiruptor
Accessions
- Primary accessionE4Q1K8
Proteomes
Subcellular Location
Interaction
Structure
Sequence
- Sequence statusComplete
- Length650
- Mass (Da)70,983
- Last updated2011-02-08 v1
- MD5 Checksum0E95B64BED5C53F9B0BAB774BB572637
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002216 EMBL· GenBank· DDBJ | ADQ04742.1 EMBL· GenBank· DDBJ | Genomic DNA |